A novel neuropeptide, Hym-355, positively regulates neuron differentiation in Hydra

Toshio Takahashi, Osamu Koizumi, Yuki Ariura, Anna Romanovitch, Thomas C.G. Bosch, Yoshitaka Kobayakawa, Shiro Mohri, Hans R. Bode, Seungshic Yum, Masayuki Hatta, Toshitaka Fujisawa

Research output: Contribution to journalArticlepeer-review

84 Citations (Scopus)


During the course of a systematic screening of peptide signaling molecules in Hydra a novel peptide, Hym-355 (FPQSFLPRG-NH2), was identified. A cDNA encoding the peptide was isolated and characterized. Using both in situ hybridization and immunohistochemistry, Hym-355 was shown to be expressed in neurons and hence is a neuropeptide. The peptide was shown to specifically enhance neuron differentiation throughout the animal by inducing interstitial cells to enter the neuron pathway. Further, co-treatment with a PW peptide, which inhibits neuron differentiation, nullified the effects of both peptides, suggesting that they act in an antagonistic manner. This effect is discussed in terms of a feedback mechanism for maintaining the steady state neuron population in Hydra.

Original languageEnglish
Pages (from-to)997-1005
Number of pages9
Issue number5
Publication statusPublished - Apr 3 2000

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Developmental Biology


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