A novel neuropeptide, Hym-355, positively regulates neuron differentiation in Hydra

Toshio Takahashi; Osamu Koizumi; Yuki Ariura; Anna Romanovitch; Thomas C.G. Bosch; Yoshitaka Kobayakawa; Shiro Mohri; Hans R. Bode; Seungshic Yum; Masayuki Hatta; Toshitaka Fujisawa

A novel neuropeptide, Hym-355, positively regulates neuron differentiation in Hydra

Toshio Takahashi, Osamu Koizumi, Yuki Ariura, Anna Romanovitch, Thomas C.G. Bosch, Yoshitaka Kobayakawa, Shiro Mohri, Hans R. Bode, Seungshic Yum, Masayuki Hatta, Toshitaka Fujisawa

Division for Experimental Natural Science

Research output: Contribution to journal › Article › peer-review

78 Citations (Scopus)

Abstract

During the course of a systematic screening of peptide signaling molecules in Hydra a novel peptide, Hym-355 (FPQSFLPRG-NH₂), was identified. A cDNA encoding the peptide was isolated and characterized. Using both in situ hybridization and immunohistochemistry, Hym-355 was shown to be expressed in neurons and hence is a neuropeptide. The peptide was shown to specifically enhance neuron differentiation throughout the animal by inducing interstitial cells to enter the neuron pathway. Further, co-treatment with a PW peptide, which inhibits neuron differentiation, nullified the effects of both peptides, suggesting that they act in an antagonistic manner. This effect is discussed in terms of a feedback mechanism for maintaining the steady state neuron population in Hydra.

Original language	English
Pages (from-to)	997-1005
Number of pages	9
Journal	Development
Volume	127
Issue number	5
Publication status	Published - Apr 3 2000

All Science Journal Classification (ASJC) codes

Molecular Biology
Developmental Biology

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A novel neuropeptide, Hym-355, positively regulates neuron differentiation in Hydra. / Takahashi, Toshio; Koizumi, Osamu; Ariura, Yuki; Romanovitch, Anna; Bosch, Thomas C.G.; Kobayakawa, Yoshitaka; Mohri, Shiro; Bode, Hans R.; Yum, Seungshic; Hatta, Masayuki; Fujisawa, Toshitaka.

In: Development, Vol. 127, No. 5, 03.04.2000, p. 997-1005.

Research output: Contribution to journal › Article › peer-review

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abstract = "During the course of a systematic screening of peptide signaling molecules in Hydra a novel peptide, Hym-355 (FPQSFLPRG-NH2), was identified. A cDNA encoding the peptide was isolated and characterized. Using both in situ hybridization and immunohistochemistry, Hym-355 was shown to be expressed in neurons and hence is a neuropeptide. The peptide was shown to specifically enhance neuron differentiation throughout the animal by inducing interstitial cells to enter the neuron pathway. Further, co-treatment with a PW peptide, which inhibits neuron differentiation, nullified the effects of both peptides, suggesting that they act in an antagonistic manner. This effect is discussed in terms of a feedback mechanism for maintaining the steady state neuron population in Hydra.",

author = "Toshio Takahashi and Osamu Koizumi and Yuki Ariura and Anna Romanovitch and Bosch, {Thomas C.G.} and Yoshitaka Kobayakawa and Shiro Mohri and Bode, {Hans R.} and Seungshic Yum and Masayuki Hatta and Toshitaka Fujisawa",

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AU - Takahashi, Toshio

AU - Koizumi, Osamu

AU - Ariura, Yuki

AU - Romanovitch, Anna

AU - Bosch, Thomas C.G.

AU - Kobayakawa, Yoshitaka

AU - Mohri, Shiro

AU - Bode, Hans R.

AU - Yum, Seungshic

AU - Hatta, Masayuki

AU - Fujisawa, Toshitaka

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AB - During the course of a systematic screening of peptide signaling molecules in Hydra a novel peptide, Hym-355 (FPQSFLPRG-NH2), was identified. A cDNA encoding the peptide was isolated and characterized. Using both in situ hybridization and immunohistochemistry, Hym-355 was shown to be expressed in neurons and hence is a neuropeptide. The peptide was shown to specifically enhance neuron differentiation throughout the animal by inducing interstitial cells to enter the neuron pathway. Further, co-treatment with a PW peptide, which inhibits neuron differentiation, nullified the effects of both peptides, suggesting that they act in an antagonistic manner. This effect is discussed in terms of a feedback mechanism for maintaining the steady state neuron population in Hydra.

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