TY - JOUR
T1 - A novel neuropeptide, Hym-355, positively regulates neuron differentiation in Hydra
AU - Takahashi, Toshio
AU - Koizumi, Osamu
AU - Ariura, Yuki
AU - Romanovitch, Anna
AU - Bosch, Thomas C.G.
AU - Kobayakawa, Yoshitaka
AU - Mohri, Shiro
AU - Bode, Hans R.
AU - Yum, Seungshic
AU - Hatta, Masayuki
AU - Fujisawa, Toshitaka
PY - 2000/4/3
Y1 - 2000/4/3
N2 - During the course of a systematic screening of peptide signaling molecules in Hydra a novel peptide, Hym-355 (FPQSFLPRG-NH2), was identified. A cDNA encoding the peptide was isolated and characterized. Using both in situ hybridization and immunohistochemistry, Hym-355 was shown to be expressed in neurons and hence is a neuropeptide. The peptide was shown to specifically enhance neuron differentiation throughout the animal by inducing interstitial cells to enter the neuron pathway. Further, co-treatment with a PW peptide, which inhibits neuron differentiation, nullified the effects of both peptides, suggesting that they act in an antagonistic manner. This effect is discussed in terms of a feedback mechanism for maintaining the steady state neuron population in Hydra.
AB - During the course of a systematic screening of peptide signaling molecules in Hydra a novel peptide, Hym-355 (FPQSFLPRG-NH2), was identified. A cDNA encoding the peptide was isolated and characterized. Using both in situ hybridization and immunohistochemistry, Hym-355 was shown to be expressed in neurons and hence is a neuropeptide. The peptide was shown to specifically enhance neuron differentiation throughout the animal by inducing interstitial cells to enter the neuron pathway. Further, co-treatment with a PW peptide, which inhibits neuron differentiation, nullified the effects of both peptides, suggesting that they act in an antagonistic manner. This effect is discussed in terms of a feedback mechanism for maintaining the steady state neuron population in Hydra.
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M3 - Article
C2 - 10662639
AN - SCOPUS:17144473790
VL - 127
SP - 997
EP - 1005
JO - Journal of Embryology and Experimental Morphology
JF - Journal of Embryology and Experimental Morphology
SN - 0950-1991
IS - 5
ER -