A novel preoperative predictor of pancreatic fistula using computed tomography after distal pancreatectomy with staple closure

Yasunari Fukuda, Daisaku Yamada, Hidetoshi Eguchi, Yoshifumi Iwagami, Takehiro Noda, Tadafumi Asaoka, Hiroshi Wada, Koichi Kawamoto, Kunihito Gotoh, Masaki Mori, Yuichiro Doki

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Purpose: A thick pancreas has proven to be a conspicuous predictor of pancreatic fistula (PF) following distal pancreatectomy (DP) using staples. Other predictors for this serious surgical complication currently remain obscure. This study sought to identify novel predictors of PF following DP. Methods: One hundred and twenty-two patients were retrospectively assessed to determine the correlation between PF occurrence and the clinicopathological findings and radiologic data from preoperative computed tomography (CT). CT assessments included the thickness of the pancreas (TP) and pancreatic CT number (pancreatic index; PI), calculated by dividing the pancreatic CT by the splenic CT density. Results: Twenty-four patients (19.7%) developed a clinically relevant PF. TP was identified as an independent risk factor for PF in multivariate analyses (odds ratio 1.17; P = 0.0095). In subgroup analyses, a lower PI in a thick pancreas was a significant predictor of PF (P = 0.032). The combination of these two prediction parameters, known as the TP-to-PI ratio (TPIR), showed a significantly better prediction ability than TP alone (area under the receiver operating characteristic curve for the incidence of PF, TPIR 0.80 vs. TP 0.69; P = 0.037). Conclusion: Combining the CT number with TP substantially improves the prediction ability for the incidence of PF following DP with staple use.

Original languageEnglish
Pages (from-to)1180-1187
Number of pages8
JournalSurgery today
Volume47
Issue number10
DOIs
Publication statusPublished - Oct 1 2017
Externally publishedYes

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Pancreatic Fistula
Pancreatectomy
Pancreas
Tomography
Incidence
ROC Curve
Multivariate Analysis
Odds Ratio

All Science Journal Classification (ASJC) codes

  • Surgery

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A novel preoperative predictor of pancreatic fistula using computed tomography after distal pancreatectomy with staple closure. / Fukuda, Yasunari; Yamada, Daisaku; Eguchi, Hidetoshi; Iwagami, Yoshifumi; Noda, Takehiro; Asaoka, Tadafumi; Wada, Hiroshi; Kawamoto, Koichi; Gotoh, Kunihito; Mori, Masaki; Doki, Yuichiro.

In: Surgery today, Vol. 47, No. 10, 01.10.2017, p. 1180-1187.

Research output: Contribution to journalArticle

Fukuda, Y, Yamada, D, Eguchi, H, Iwagami, Y, Noda, T, Asaoka, T, Wada, H, Kawamoto, K, Gotoh, K, Mori, M & Doki, Y 2017, 'A novel preoperative predictor of pancreatic fistula using computed tomography after distal pancreatectomy with staple closure', Surgery today, vol. 47, no. 10, pp. 1180-1187. https://doi.org/10.1007/s00595-017-1495-9
Fukuda, Yasunari ; Yamada, Daisaku ; Eguchi, Hidetoshi ; Iwagami, Yoshifumi ; Noda, Takehiro ; Asaoka, Tadafumi ; Wada, Hiroshi ; Kawamoto, Koichi ; Gotoh, Kunihito ; Mori, Masaki ; Doki, Yuichiro. / A novel preoperative predictor of pancreatic fistula using computed tomography after distal pancreatectomy with staple closure. In: Surgery today. 2017 ; Vol. 47, No. 10. pp. 1180-1187.
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abstract = "Purpose: A thick pancreas has proven to be a conspicuous predictor of pancreatic fistula (PF) following distal pancreatectomy (DP) using staples. Other predictors for this serious surgical complication currently remain obscure. This study sought to identify novel predictors of PF following DP. Methods: One hundred and twenty-two patients were retrospectively assessed to determine the correlation between PF occurrence and the clinicopathological findings and radiologic data from preoperative computed tomography (CT). CT assessments included the thickness of the pancreas (TP) and pancreatic CT number (pancreatic index; PI), calculated by dividing the pancreatic CT by the splenic CT density. Results: Twenty-four patients (19.7{\%}) developed a clinically relevant PF. TP was identified as an independent risk factor for PF in multivariate analyses (odds ratio 1.17; P = 0.0095). In subgroup analyses, a lower PI in a thick pancreas was a significant predictor of PF (P = 0.032). The combination of these two prediction parameters, known as the TP-to-PI ratio (TPIR), showed a significantly better prediction ability than TP alone (area under the receiver operating characteristic curve for the incidence of PF, TPIR 0.80 vs. TP 0.69; P = 0.037). Conclusion: Combining the CT number with TP substantially improves the prediction ability for the incidence of PF following DP with staple use.",
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AU - Yamada, Daisaku

AU - Eguchi, Hidetoshi

AU - Iwagami, Yoshifumi

AU - Noda, Takehiro

AU - Asaoka, Tadafumi

AU - Wada, Hiroshi

AU - Kawamoto, Koichi

AU - Gotoh, Kunihito

AU - Mori, Masaki

AU - Doki, Yuichiro

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N2 - Purpose: A thick pancreas has proven to be a conspicuous predictor of pancreatic fistula (PF) following distal pancreatectomy (DP) using staples. Other predictors for this serious surgical complication currently remain obscure. This study sought to identify novel predictors of PF following DP. Methods: One hundred and twenty-two patients were retrospectively assessed to determine the correlation between PF occurrence and the clinicopathological findings and radiologic data from preoperative computed tomography (CT). CT assessments included the thickness of the pancreas (TP) and pancreatic CT number (pancreatic index; PI), calculated by dividing the pancreatic CT by the splenic CT density. Results: Twenty-four patients (19.7%) developed a clinically relevant PF. TP was identified as an independent risk factor for PF in multivariate analyses (odds ratio 1.17; P = 0.0095). In subgroup analyses, a lower PI in a thick pancreas was a significant predictor of PF (P = 0.032). The combination of these two prediction parameters, known as the TP-to-PI ratio (TPIR), showed a significantly better prediction ability than TP alone (area under the receiver operating characteristic curve for the incidence of PF, TPIR 0.80 vs. TP 0.69; P = 0.037). Conclusion: Combining the CT number with TP substantially improves the prediction ability for the incidence of PF following DP with staple use.

AB - Purpose: A thick pancreas has proven to be a conspicuous predictor of pancreatic fistula (PF) following distal pancreatectomy (DP) using staples. Other predictors for this serious surgical complication currently remain obscure. This study sought to identify novel predictors of PF following DP. Methods: One hundred and twenty-two patients were retrospectively assessed to determine the correlation between PF occurrence and the clinicopathological findings and radiologic data from preoperative computed tomography (CT). CT assessments included the thickness of the pancreas (TP) and pancreatic CT number (pancreatic index; PI), calculated by dividing the pancreatic CT by the splenic CT density. Results: Twenty-four patients (19.7%) developed a clinically relevant PF. TP was identified as an independent risk factor for PF in multivariate analyses (odds ratio 1.17; P = 0.0095). In subgroup analyses, a lower PI in a thick pancreas was a significant predictor of PF (P = 0.032). The combination of these two prediction parameters, known as the TP-to-PI ratio (TPIR), showed a significantly better prediction ability than TP alone (area under the receiver operating characteristic curve for the incidence of PF, TPIR 0.80 vs. TP 0.69; P = 0.037). Conclusion: Combining the CT number with TP substantially improves the prediction ability for the incidence of PF following DP with staple use.

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