A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells

Hitoshi Nishimura, Toshiki Yajima, Hiromi Muta, Eckhard R. Podack, Kenzaburo Tani, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    34 Citations (Scopus)

    Abstract

    Memory CD8+ T cells can be divided into two subsets, central memory (TCM) and effector memory (TEM) CD8+ T cells. We foend that CD30, a member of the TNFR-associated factor (TRAF)-linked TNFR seperfamily, signaling is involved in differentiation of long-lived CD8+ TCM cells following Listeria monocytogenes infection. Although CD8+ TEM cells transiently accumulated in the noalymphoid tissues of CD30 ligand (CD153-/-) mice after infection, long-lived memory CD8+ TCM cells were poorly generated in these mice. CCR7 mRNA expression was down-regulated in CD8+ T cells of the spleen of CD153-/- mice in vivo and the expression was up-regulated in CD8+ TEM cells by anti-CD30 mAb cross-linking in vitro. These results suggest that CD30/CD30 ligand signaling plays an important role in the generation of long-lived memory CD8+ T cells at least partly by triggering homing receptors for TCM cells.

    Original languageEnglish
    Pages (from-to)4627-4634
    Number of pages8
    JournalJournal of Immunology
    Volume175
    Issue number7
    DOIs
    Publication statusPublished - Oct 1 2005

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    CD30 Ligand
    T-Lymphocytes
    Listeriosis
    Listeria monocytogenes
    Spleen
    Messenger RNA
    Infection

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

    Cite this

    Nishimura, H., Yajima, T., Muta, H., Podack, E. R., Tani, K., & Yoshikai, Y. (2005). A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells. Journal of Immunology, 175(7), 4627-4634. https://doi.org/10.4049/jimmunol.175.7.4627

    A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells. / Nishimura, Hitoshi; Yajima, Toshiki; Muta, Hiromi; Podack, Eckhard R.; Tani, Kenzaburo; Yoshikai, Yasunobu.

    In: Journal of Immunology, Vol. 175, No. 7, 01.10.2005, p. 4627-4634.

    Research output: Contribution to journalArticle

    Nishimura, H, Yajima, T, Muta, H, Podack, ER, Tani, K & Yoshikai, Y 2005, 'A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells', Journal of Immunology, vol. 175, no. 7, pp. 4627-4634. https://doi.org/10.4049/jimmunol.175.7.4627
    Nishimura, Hitoshi ; Yajima, Toshiki ; Muta, Hiromi ; Podack, Eckhard R. ; Tani, Kenzaburo ; Yoshikai, Yasunobu. / A novel role of CD30/CD30 ligand signaling in the generation of long-lived memory CD8+ T cells. In: Journal of Immunology. 2005 ; Vol. 175, No. 7. pp. 4627-4634.
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