A novel role of IL-15 in early activation of memory CD8+ CTL after reinfection

Toshiki Yajima, Hitoshi Nishimura, Subash Sad, Hao Shen, Hiroyuki Kuwano, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

    36 Citations (Scopus)

    Abstract

    A rapid induction of effector functions in memory T cells provides rapid and intensified protection against reinfection. To determine potential roles of IL-15 in early expansion and activation of memory CD8+ T cells in secondary immune response, we examined the cell division and cytotoxicity of memory CD8+ T cells expressing OVA257-264/K b-specific TCR that were transferred into IL-15-transgenic (Tg) mice, IL-15 knockout (KO) mice, or control C57BL/6 mice followed by challenge with recombinant Listeria monocytogenes expressing OVA (rLM-OVA). In vivo CTL activities and expression of granzyme B of the transferred CD8+ T cells were significantly higher in the IL-15 Tg mice but lower in the IL-15 KO mice than those in control mice at the early stage after challenge with rLM-OVA. In contrast, there was no difference in the cell division in IL-15 Tg mice and IL-15 KO mice compared with those in control mice. In vivo administration of rIL-15 conferred robust protection against reinfection via induction of granzyme B in the memory CD8+ T cells. These results suggest that IL-15 plays an important role in early activation of memory CD8+ T cells.

    Original languageEnglish
    Pages (from-to)3590-3597
    Number of pages8
    JournalJournal of Immunology
    Volume174
    Issue number6
    DOIs
    Publication statusPublished - Mar 15 2005

    Fingerprint

    Interleukin-15
    T-Lymphocytes
    Knockout Mice
    Transgenic Mice
    Granzymes
    Listeria monocytogenes
    Cell Division
    Inbred C57BL Mouse

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

    Cite this

    Yajima, T., Nishimura, H., Sad, S., Shen, H., Kuwano, H., & Yoshikai, Y. (2005). A novel role of IL-15 in early activation of memory CD8+ CTL after reinfection. Journal of Immunology, 174(6), 3590-3597. https://doi.org/10.4049/jimmunol.174.6.3590

    A novel role of IL-15 in early activation of memory CD8+ CTL after reinfection. / Yajima, Toshiki; Nishimura, Hitoshi; Sad, Subash; Shen, Hao; Kuwano, Hiroyuki; Yoshikai, Yasunobu.

    In: Journal of Immunology, Vol. 174, No. 6, 15.03.2005, p. 3590-3597.

    Research output: Contribution to journalArticle

    Yajima, T, Nishimura, H, Sad, S, Shen, H, Kuwano, H & Yoshikai, Y 2005, 'A novel role of IL-15 in early activation of memory CD8+ CTL after reinfection', Journal of Immunology, vol. 174, no. 6, pp. 3590-3597. https://doi.org/10.4049/jimmunol.174.6.3590
    Yajima, Toshiki ; Nishimura, Hitoshi ; Sad, Subash ; Shen, Hao ; Kuwano, Hiroyuki ; Yoshikai, Yasunobu. / A novel role of IL-15 in early activation of memory CD8+ CTL after reinfection. In: Journal of Immunology. 2005 ; Vol. 174, No. 6. pp. 3590-3597.
    @article{2031eaa80e444cd19562ba799da5aa70,
    title = "A novel role of IL-15 in early activation of memory CD8+ CTL after reinfection",
    abstract = "A rapid induction of effector functions in memory T cells provides rapid and intensified protection against reinfection. To determine potential roles of IL-15 in early expansion and activation of memory CD8+ T cells in secondary immune response, we examined the cell division and cytotoxicity of memory CD8+ T cells expressing OVA257-264/K b-specific TCR that were transferred into IL-15-transgenic (Tg) mice, IL-15 knockout (KO) mice, or control C57BL/6 mice followed by challenge with recombinant Listeria monocytogenes expressing OVA (rLM-OVA). In vivo CTL activities and expression of granzyme B of the transferred CD8+ T cells were significantly higher in the IL-15 Tg mice but lower in the IL-15 KO mice than those in control mice at the early stage after challenge with rLM-OVA. In contrast, there was no difference in the cell division in IL-15 Tg mice and IL-15 KO mice compared with those in control mice. In vivo administration of rIL-15 conferred robust protection against reinfection via induction of granzyme B in the memory CD8+ T cells. These results suggest that IL-15 plays an important role in early activation of memory CD8+ T cells.",
    author = "Toshiki Yajima and Hitoshi Nishimura and Subash Sad and Hao Shen and Hiroyuki Kuwano and Yasunobu Yoshikai",
    year = "2005",
    month = "3",
    day = "15",
    doi = "10.4049/jimmunol.174.6.3590",
    language = "English",
    volume = "174",
    pages = "3590--3597",
    journal = "Journal of Immunology",
    issn = "0022-1767",
    publisher = "American Association of Immunologists",
    number = "6",

    }

    TY - JOUR

    T1 - A novel role of IL-15 in early activation of memory CD8+ CTL after reinfection

    AU - Yajima, Toshiki

    AU - Nishimura, Hitoshi

    AU - Sad, Subash

    AU - Shen, Hao

    AU - Kuwano, Hiroyuki

    AU - Yoshikai, Yasunobu

    PY - 2005/3/15

    Y1 - 2005/3/15

    N2 - A rapid induction of effector functions in memory T cells provides rapid and intensified protection against reinfection. To determine potential roles of IL-15 in early expansion and activation of memory CD8+ T cells in secondary immune response, we examined the cell division and cytotoxicity of memory CD8+ T cells expressing OVA257-264/K b-specific TCR that were transferred into IL-15-transgenic (Tg) mice, IL-15 knockout (KO) mice, or control C57BL/6 mice followed by challenge with recombinant Listeria monocytogenes expressing OVA (rLM-OVA). In vivo CTL activities and expression of granzyme B of the transferred CD8+ T cells were significantly higher in the IL-15 Tg mice but lower in the IL-15 KO mice than those in control mice at the early stage after challenge with rLM-OVA. In contrast, there was no difference in the cell division in IL-15 Tg mice and IL-15 KO mice compared with those in control mice. In vivo administration of rIL-15 conferred robust protection against reinfection via induction of granzyme B in the memory CD8+ T cells. These results suggest that IL-15 plays an important role in early activation of memory CD8+ T cells.

    AB - A rapid induction of effector functions in memory T cells provides rapid and intensified protection against reinfection. To determine potential roles of IL-15 in early expansion and activation of memory CD8+ T cells in secondary immune response, we examined the cell division and cytotoxicity of memory CD8+ T cells expressing OVA257-264/K b-specific TCR that were transferred into IL-15-transgenic (Tg) mice, IL-15 knockout (KO) mice, or control C57BL/6 mice followed by challenge with recombinant Listeria monocytogenes expressing OVA (rLM-OVA). In vivo CTL activities and expression of granzyme B of the transferred CD8+ T cells were significantly higher in the IL-15 Tg mice but lower in the IL-15 KO mice than those in control mice at the early stage after challenge with rLM-OVA. In contrast, there was no difference in the cell division in IL-15 Tg mice and IL-15 KO mice compared with those in control mice. In vivo administration of rIL-15 conferred robust protection against reinfection via induction of granzyme B in the memory CD8+ T cells. These results suggest that IL-15 plays an important role in early activation of memory CD8+ T cells.

    UR - http://www.scopus.com/inward/record.url?scp=14844364003&partnerID=8YFLogxK

    UR - http://www.scopus.com/inward/citedby.url?scp=14844364003&partnerID=8YFLogxK

    U2 - 10.4049/jimmunol.174.6.3590

    DO - 10.4049/jimmunol.174.6.3590

    M3 - Article

    C2 - 15749896

    AN - SCOPUS:14844364003

    VL - 174

    SP - 3590

    EP - 3597

    JO - Journal of Immunology

    JF - Journal of Immunology

    SN - 0022-1767

    IS - 6

    ER -