A novel role of periostin in postnatal tooth formation and mineralization

Dedong Ma, Rong Zhang, Yao Sun, Hector F. Rios, Naoto Haruyama, Xianglong Han, Ashok B. Kulkarni, Chunlin Qin, Jian Q. Feng

Research output: Contribution to journalArticle

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Abstract

Periostin plays multiple functions during development. Our previous work showed a critical role of this disulfide-linked cell adhesion protein in maintenance of periodontium integrity in response to occlusal load. In this study, we attempted to address whether this mechanical response molecule played a direct role in postnatal tooth development. Our key findings are 1) periostin is expressed in preodontoblasts, and odontoblasts; and the periostin-null incisor displayed a massive increase in dentin formation after mastication; 2) periostin is also expressed in the ameloblast cells, and an enamel defect is identified in both the adult-null incisor and molar; 3) deletion of periostin leads to changes in expression profiles of many non-collagenous protein such as DSPP, DMP1, BSP, and OPN in incisor dentin; 4) the removal of a biting force leads to reduction of mineralization, which is partially prevented in periostin-null mice; and 6) both in vitro and in vivo data revealed a direct regulation of periostin by TGF-β1 in dentin formation. In conclusion, periostin plays a novel direct role in controlling postnatal tooth formation, which is required for the integrity of both enamel and dentin.

Original languageEnglish
Pages (from-to)4302-4309
Number of pages8
JournalJournal of Biological Chemistry
Volume286
Issue number6
DOIs
Publication statusPublished - Feb 11 2011

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Enamels
Dentin
Tooth
Incisor
Mastication
Cell adhesion
Dental Enamel
Disulfides
Proteins
Ameloblasts
Odontoblasts
Periodontium
Defects
Molecules
Cell Adhesion
Maintenance

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

A novel role of periostin in postnatal tooth formation and mineralization. / Ma, Dedong; Zhang, Rong; Sun, Yao; Rios, Hector F.; Haruyama, Naoto; Han, Xianglong; Kulkarni, Ashok B.; Qin, Chunlin; Feng, Jian Q.

In: Journal of Biological Chemistry, Vol. 286, No. 6, 11.02.2011, p. 4302-4309.

Research output: Contribution to journalArticle

Ma, D, Zhang, R, Sun, Y, Rios, HF, Haruyama, N, Han, X, Kulkarni, AB, Qin, C & Feng, JQ 2011, 'A novel role of periostin in postnatal tooth formation and mineralization', Journal of Biological Chemistry, vol. 286, no. 6, pp. 4302-4309. https://doi.org/10.1074/jbc.M110.140202
Ma, Dedong ; Zhang, Rong ; Sun, Yao ; Rios, Hector F. ; Haruyama, Naoto ; Han, Xianglong ; Kulkarni, Ashok B. ; Qin, Chunlin ; Feng, Jian Q. / A novel role of periostin in postnatal tooth formation and mineralization. In: Journal of Biological Chemistry. 2011 ; Vol. 286, No. 6. pp. 4302-4309.
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