A novel synthesis of cyclohexylnorstatine isopropyl ester, the C-terminal component of a renin inhibitor

Yoshio Ito, Tetsuhide Kamijo, Hiromu Harada, Shiro Terashima

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The title compound was produced diastereoselectively in racemic and optically active forms by employing the [2 + 2] cycloaddition reaction of an imine with benzyloxyketene followed by acidic alcoholysis of the formed 3,4-cis-disubstituted β-lactam with isopropanol.

Original languageEnglish
Pages (from-to)299-302
Number of pages4
JournalHeterocycles
Volume30
Issue number1
Publication statusPublished - Jan 1 1990
Externally publishedYes

Fingerprint

Lactams
Imines
Cycloaddition
2-Propanol
Cycloaddition Reaction
Renin
calcium ascorbate
cyclohexylnorstatine

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Cite this

A novel synthesis of cyclohexylnorstatine isopropyl ester, the C-terminal component of a renin inhibitor. / Ito, Yoshio; Kamijo, Tetsuhide; Harada, Hiromu; Terashima, Shiro.

In: Heterocycles, Vol. 30, No. 1, 01.01.1990, p. 299-302.

Research output: Contribution to journalArticle

Ito, Yoshio ; Kamijo, Tetsuhide ; Harada, Hiromu ; Terashima, Shiro. / A novel synthesis of cyclohexylnorstatine isopropyl ester, the C-terminal component of a renin inhibitor. In: Heterocycles. 1990 ; Vol. 30, No. 1. pp. 299-302.
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