A novel synthesis of cyclohexylnorstatine isopropyl ester, the C-terminal component of a renin inhibitor

Yoshio Ito; Tetsuhide Kamijo; Hiromu Harada; Shiro Terashima

doi:10.3987/com-89-s41

A novel synthesis of cyclohexylnorstatine isopropyl ester, the C-terminal component of a renin inhibitor

Yoshio Ito, Tetsuhide Kamijo, Hiromu Harada, Shiro Terashima

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The title compound was produced diastereoselectively in racemic and optically active forms by employing the [2 + 2] cycloaddition reaction of an imine with benzyloxyketene followed by acidic alcoholysis of the formed 3,4-cis-disubstituted β-lactam with isopropanol.

Original language	English
Pages (from-to)	299-302
Number of pages	4
Journal	Heterocycles
Volume	30
Issue number	1
DOIs	https://doi.org/10.3987/com-89-s41
Publication status	Published - Jan 1 1990
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Pharmacology
Organic Chemistry

Access to Document

10.3987/com-89-s41

Cite this

@article{5de96768db7b4bc18cab99b9f968f125,

title = "A novel synthesis of cyclohexylnorstatine isopropyl ester, the C-terminal component of a renin inhibitor",

abstract = "The title compound was produced diastereoselectively in racemic and optically active forms by employing the [2 + 2] cycloaddition reaction of an imine with benzyloxyketene followed by acidic alcoholysis of the formed 3,4-cis-disubstituted β-lactam with isopropanol.",

author = "Yoshio Ito and Tetsuhide Kamijo and Hiromu Harada and Shiro Terashima",

year = "1990",

month = jan,

day = "1",

doi = "10.3987/com-89-s41",

language = "English",

volume = "30",

pages = "299--302",

journal = "Heterocycles",

issn = "0385-5414",

publisher = "Japan Institute of Heterocyclic Chemistry",

number = "1",

}

TY - JOUR

T1 - A novel synthesis of cyclohexylnorstatine isopropyl ester, the C-terminal component of a renin inhibitor

AU - Ito, Yoshio

AU - Kamijo, Tetsuhide

AU - Harada, Hiromu

AU - Terashima, Shiro

PY - 1990/1/1

Y1 - 1990/1/1

N2 - The title compound was produced diastereoselectively in racemic and optically active forms by employing the [2 + 2] cycloaddition reaction of an imine with benzyloxyketene followed by acidic alcoholysis of the formed 3,4-cis-disubstituted β-lactam with isopropanol.

AB - The title compound was produced diastereoselectively in racemic and optically active forms by employing the [2 + 2] cycloaddition reaction of an imine with benzyloxyketene followed by acidic alcoholysis of the formed 3,4-cis-disubstituted β-lactam with isopropanol.

UR - http://www.scopus.com/inward/record.url?scp=0142199048&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0142199048&partnerID=8YFLogxK

U2 - 10.3987/com-89-s41

DO - 10.3987/com-89-s41

M3 - Article

AN - SCOPUS:0142199048

VL - 30

SP - 299

EP - 302

JO - Heterocycles

JF - Heterocycles

SN - 0385-5414

IS - 1

ER -

A novel synthesis of cyclohexylnorstatine isopropyl ester, the C-terminal component of a renin inhibitor

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this