TY - JOUR
T1 - A novel Vβ 2-specific endogenous mouse mammary tumor virus which is capable of producing a milk-borne exogenous virus
AU - Niimi, Naoya
AU - Wajjwalku, Worawidh
AU - Ando, Yoshihiro
AU - Nakamura, Nobuhisa
AU - Ueda, Minoru
AU - Yoshikai, Yasunobu
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1995/11
Y1 - 1995/11
N2 - We have previously reported new Mtv loci, Mtv-48 and -51, in the Japanese laboratory mouse strains CS and NC. Here we show by backcross analysis that both Mtv-48 and -51 cosegregate with very slow deletion of T cells bearing Vβ 2. The nucleotide sequences of the open reading frames in the 3' long terminal repeats of Mtv-48 and -51 were very similar to those of Mtv-DDO, mouse mammary tumor virus C4 [MMTV(C4)], and MMTV(BALB/cV), which encode Vβ 2-specific superantigens. Furthermore, backcross female mice carrying Mtv-48 but not Mtv-51 were found to be able to produce milk-borne MMTV(CS), which can vigorously stimulate Vβ 2-expressing T cells after local injection in vivo in an I-E-dependent manner. On the other hand, mice carrying Mtv-51 but not Mtv-48 could not produce such an MMTV in milk. The nucleotide sequences of MMTV(CS) open reading frame were completely matched with those of Mtv-48. These results indicate that the provirus Mtv-48 but not Mtv-51 is capable of producing a milk-borne virus of which the superantigen stimulates Vβ 2- expressing T cells.
AB - We have previously reported new Mtv loci, Mtv-48 and -51, in the Japanese laboratory mouse strains CS and NC. Here we show by backcross analysis that both Mtv-48 and -51 cosegregate with very slow deletion of T cells bearing Vβ 2. The nucleotide sequences of the open reading frames in the 3' long terminal repeats of Mtv-48 and -51 were very similar to those of Mtv-DDO, mouse mammary tumor virus C4 [MMTV(C4)], and MMTV(BALB/cV), which encode Vβ 2-specific superantigens. Furthermore, backcross female mice carrying Mtv-48 but not Mtv-51 were found to be able to produce milk-borne MMTV(CS), which can vigorously stimulate Vβ 2-expressing T cells after local injection in vivo in an I-E-dependent manner. On the other hand, mice carrying Mtv-51 but not Mtv-48 could not produce such an MMTV in milk. The nucleotide sequences of MMTV(CS) open reading frame were completely matched with those of Mtv-48. These results indicate that the provirus Mtv-48 but not Mtv-51 is capable of producing a milk-borne virus of which the superantigen stimulates Vβ 2- expressing T cells.
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U2 - 10.1128/jvi.69.11.7269-7273.1995
DO - 10.1128/jvi.69.11.7269-7273.1995
M3 - Article
C2 - 7474151
AN - SCOPUS:0028971164
VL - 69
SP - 7269
EP - 7273
JO - Journal of Virology
JF - Journal of Virology
SN - 0022-538X
IS - 11
ER -