A novel Vβ 2-specific endogenous mouse mammary tumor virus which is capable of producing a milk-borne exogenous virus

Naoya Niimi, Worawidh Wajjwalku, Yoshihiro Ando, Nobuhisa Nakamura, Minoru Ueda, Yasunobu Yoshikai

    Research output: Contribution to journalArticlepeer-review

    11 Citations (Scopus)

    Abstract

    We have previously reported new Mtv loci, Mtv-48 and -51, in the Japanese laboratory mouse strains CS and NC. Here we show by backcross analysis that both Mtv-48 and -51 cosegregate with very slow deletion of T cells bearing Vβ 2. The nucleotide sequences of the open reading frames in the 3' long terminal repeats of Mtv-48 and -51 were very similar to those of Mtv-DDO, mouse mammary tumor virus C4 [MMTV(C4)], and MMTV(BALB/cV), which encode Vβ 2-specific superantigens. Furthermore, backcross female mice carrying Mtv-48 but not Mtv-51 were found to be able to produce milk-borne MMTV(CS), which can vigorously stimulate Vβ 2-expressing T cells after local injection in vivo in an I-E-dependent manner. On the other hand, mice carrying Mtv-51 but not Mtv-48 could not produce such an MMTV in milk. The nucleotide sequences of MMTV(CS) open reading frame were completely matched with those of Mtv-48. These results indicate that the provirus Mtv-48 but not Mtv-51 is capable of producing a milk-borne virus of which the superantigen stimulates Vβ 2- expressing T cells.

    Original languageEnglish
    Pages (from-to)7269-7273
    Number of pages5
    JournalJournal of virology
    Volume69
    Issue number11
    DOIs
    Publication statusPublished - Nov 1995

    All Science Journal Classification (ASJC) codes

    • Microbiology
    • Immunology
    • Insect Science
    • Virology

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