A patient with Alzheimer's disease complicated by elderly-onset Cushing's syndrome who had undergone surgical treatment for adrenocorticotropic hormone-independent macronodular adrenal hyperplasia

Yoshinori Haraguchi, Yoshito Mizoguchi, Tomoyuki Noguchi, Takeo Arai, Junko Fukuyama, Takahiro A. Kato, Toshiro Kawashima, Akira Monji

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Cushing's syndrome (CS) is a rare disorder, especially in older people. Loss of brain volume and neurocognitive impairment of varying degrees has been demonstrated in patients with CS. However, there is a large difference between the median age of presentation of CS and that of Alzheimer's disease. We herein report a case of a patient with Alzheimer's disease complicated by elderly-onset CS who had undergone surgical treatment for adrenal hyperplasia. Surgical correction of hypercortisolism seems to have slowed the progression of brain volume loss and cognitive dysfunction and improved psychiatric symptoms such as visual hallucination, restlessness, and psychomotor excitement. These improvements have remarkably reduced the burden on the patient's caregivers. The present case suggests that subclinical CS may be present, particularly in rapidly progressive dementia, and that surgical treatment of CS for neuropsychiatric symptoms is useful.

Original languageEnglish
Pages (from-to)274-276
Number of pages3
JournalPsychogeriatrics
Volume16
Issue number4
DOIs
Publication statusPublished - Jul 1 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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