A patient with Cotard syndrome who showed an improvement in single photon emission computed tomography findings after successful treatment with antidepressants

Sadayuki Hashioka, Akira Monji, Masayuki Sasaki, Ichiro Yoshida, Kanji Baba, Nobutada Tashiro

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

We report the case of a presenile woman with Cotard syndrome, in the context of major depression, who showed an improvement in bilateral frontal hypoperfusion in a SPECT study using 99mTc-HMPAO after undergoing successful treatment with antidepressant therapy. We also retrospectively evaluated her clinical course based on the clinical stages. The symptoms of Cotard syndrome have been reported to change dramatically according to the stages. This peculiarity made it difficult for us to rapidly diagnose Cotard syndrome in the context of major depression, and not dementia, and thereby adequately treat the patient in our case. Differences in the reduced blood flow regions and a time lag from psychiatric remission were observed before the improvement in the SPECT findings when comparing our case with a previously reported case of Cotard syndrome. These differences suggest that the mechanism of Cotard syndrome is still not well understood at the present time.

Original languageEnglish
Pages (from-to)276-279
Number of pages4
JournalClinical Neuropharmacology
Volume25
Issue number5
DOIs
Publication statusPublished - Sep 2002

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)

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