A patient with primary human immunodeficiency virus infection for whom highly active antiretroviral therapy was successful

Norihiro Furusyo, Iwao Ariyama, Yong Chong, Masao Harada, Shigeki Nabeshima, Arahito Mitsutake, Seizaburo Kashiwagi, Jun Hayashi

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Abstract

We report the case of a 25-year-old male Japanese homosexual with primary human immunodeficier virus (HIV)-1 infection and early stage syphilis. Approximately 60 days after HIV exposure by sex with another man, the patient abruptly had high fever, after which he experienced a variety of severe, prolonged symptoms such as painful oral mucosa ulcerations, rash, lymphadenopathy, splenomegaly, and a 5.5-kg weight loss. Serum lactate dehydrogenase and liver biochemical test values were elevated. Antibodies to HIV by both enzyme-linked immunosorbent assay (ELISA) and Western blot (WB) test were negative at the time of symptom onset, but serum HIV-1 RNA level was 1585000 copies/ml. Antibody seroconversions were found on day 9 after the onset of symptoms by ELISA and on day 16 by WB test, suggesting primary HIV infection. Within 2 weeks of starting highly active antiretroviral therapy (HAART), all symptoms except lymphadenopathy were resolved, and the serum HIV-1 RNA level dramatically decreased to 5011 copies/ml, eventually becoming undetectable by the standard method. The patient has remained asymptomatic for the 18 months since symptom resolution after HAART, and HIV-1 RNA remains undetectable.

Original languageEnglish
Pages (from-to)361-364
Number of pages4
JournalJournal of Infection and Chemotherapy
Volume8
Issue number4
DOIs
Publication statusPublished - Dec 2002

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Highly Active Antiretroviral Therapy
Virus Diseases
HIV
RNA Viruses
Western Blotting
Serum
Enzyme-Linked Immunosorbent Assay
Viruses
Antibodies
Splenomegaly
Mouth Mucosa
Syphilis
Exanthema
L-Lactate Dehydrogenase
Weight Loss
Fever
Liver

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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A patient with primary human immunodeficiency virus infection for whom highly active antiretroviral therapy was successful. / Furusyo, Norihiro; Ariyama, Iwao; Chong, Yong; Harada, Masao; Nabeshima, Shigeki; Mitsutake, Arahito; Kashiwagi, Seizaburo; Hayashi, Jun.

In: Journal of Infection and Chemotherapy, Vol. 8, No. 4, 12.2002, p. 361-364.

Research output: Contribution to journalArticle

Furusyo, Norihiro ; Ariyama, Iwao ; Chong, Yong ; Harada, Masao ; Nabeshima, Shigeki ; Mitsutake, Arahito ; Kashiwagi, Seizaburo ; Hayashi, Jun. / A patient with primary human immunodeficiency virus infection for whom highly active antiretroviral therapy was successful. In: Journal of Infection and Chemotherapy. 2002 ; Vol. 8, No. 4. pp. 361-364.
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