A pediatric intramedullary spinal cord tumor with unusual solid-cystic and papillary features: A case report

Takeshi Iwasaki, Masako Kato, Yasushi Horie, Shinsuke Kato, Keiichi Akatsuka, Takashi Watanabe, Satoshi Kuwamoto, Ichiro Murakami, Kazuhiko Hayashi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Spinal cord tumors are rare in children. We report a novel case of pediatric intramedullary spinal cord tumor with unusual solid-cystic and papillary features. Clinically, the patient presented at the age of 3 years with motor deficit and urinary incontinence, and MRI demonstrated multilocular cystic lesions in the thoracic spine. Histologically the tumor consisted of solid, sheet-like components and branching papillary structures, and immunohistochemistry demonstrated positive reactivity for epithelial membrane antigen, cytokeratins (7, AE1/3, CAM5.2), E-cadherin and transthyretin, and negativity for GFAP, S-100 protein, synaptophysin and neurofilament. These histological and immunohistochemical findings appeared to be unique, and were not compatible with the features of classical ependymoma or choroid plexus papilloma. The clinical behavior, characterized by relatively rapid tumor regrowth after surgical resection and a relatively high MIB-1 labeling index, suggest that this tumor might have had moderate malignant potential. This pediatric case appears to be particularly informative with regard to the tumor biology or tumorigenesis of intramedullary spinal cord tumor with unusual solid-cystic and papillary features.

Original languageEnglish
Pages (from-to)632-638
Number of pages7
JournalNeuropathology
Volume31
Issue number6
DOIs
Publication statusPublished - Dec 2011
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Clinical Neurology

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