A peptide motif recognizing a polymer stereoregularity

Takeshi Serizawa; Toshiki Sawada; Hisao Matsuno; Teruhiko Matsubara; Toshinori Sato

doi:10.1021/ja054402o

A peptide motif recognizing a polymer stereoregularity

Takeshi Serizawa, Toshiki Sawada, Hisao Matsuno, Teruhiko Matsubara, Toshinori Sato

Research output: Contribution to journal › Article › peer-review

82 Citations (Scopus)

Abstract

A combinatorial phage display method was applied to films composed of a stereoregular polymer of methacrylates. The phage clones with selective affinity for isotactic (it) poly(methyl methacrylate) (PMMA) were isolated. Greater amounts of the phage clones bound to it-PMMA, compared to other stereoregular PMMAs. The phage expressing ELWRPTR most strongly bound to the polymer, and the selectivity was also the best. The peptide motif essential for the specific interaction with the stereoregular polymer was revealed.

Original language	English
Pages (from-to)	13780-13781
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	127
Issue number	40
DOIs	https://doi.org/10.1021/ja054402o
Publication status	Published - Oct 12 2005
Externally published	Yes

All Science Journal Classification (ASJC) codes

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja054402o

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AU - Serizawa, Takeshi

AU - Sawada, Toshiki

AU - Matsuno, Hisao

AU - Matsubara, Teruhiko

AU - Sato, Toshinori

PY - 2005/10/12

Y1 - 2005/10/12

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AB - A combinatorial phage display method was applied to films composed of a stereoregular polymer of methacrylates. The phage clones with selective affinity for isotactic (it) poly(methyl methacrylate) (PMMA) were isolated. Greater amounts of the phage clones bound to it-PMMA, compared to other stereoregular PMMAs. The phage expressing ELWRPTR most strongly bound to the polymer, and the selectivity was also the best. The peptide motif essential for the specific interaction with the stereoregular polymer was revealed.

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JF - Journal of the American Chemical Society

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A peptide motif recognizing a polymer stereoregularity

Abstract

All Science Journal Classification (ASJC) codes

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