A peroxisome proliferator-activated receptor γ agonist influenced daily profile of energy expenditure in genetically obese diabetic rats

Yuki Yoshida, Mineko Ichikawa, Minoru Ohta, Setsuko Kanai, Mikako Kobayashi, Yuhei Ichimaru, Takao Shimazoe, Shigenori Watanabe, Akihiro Funakoshi, Kyoko Miyasaka

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Otsuka Long Evans Tokushima Fatty (OLETF) rats were developed as a model of non-insulin-dependent diabetes mellitus (NIDDM) with mild obesity. We reported that the daily profiles of energy expenditure associated with two peaks (one between 05:00 and 08:00 and the other between 20:00 and 22:00) were observed at 8 weeks of age (without NIDDM), while these two peaks disappeared at 24 weeks of age with NIDDM. As a new anti-diabetic drug, a peroxisome proliferator-activated receptor γ agonist pioglitazone hydrochloride has been developed, we examined whether pioglitazone normalized daily profiles of energy expenditure at 24 weeks of age. A control diet and pioglitazone (0.1%)-containing diet were fed from 6 weeks of age. The two peaks of daily profiles of energy expenditure, which disappeared in OLETF rats with the control diet at 24 weeks of age, were reproduced by administration of pioglitazone. The respiratory quotient was lower and fat derived energy used for combustion was increased by pioglitazone at both ages. The body weight, daily food intake, plasma levels of fat, insulin, leptin and the wet weight of visceral fat were not influenced, but the levels of blood hemoglobin A1c and plasma tumor necrosis factor α were decreased by pioglitazone. Administration of pioglitazone improved daily profiles of energy expenditure via affecting glucose and fat metabolisms.

Original languageEnglish
Pages (from-to)279-284
Number of pages6
JournalJapanese Journal of Pharmacology
Volume88
Issue number3
DOIs
Publication statusPublished - 2002

All Science Journal Classification (ASJC) codes

  • Pharmacology

Fingerprint Dive into the research topics of 'A peroxisome proliferator-activated receptor γ agonist influenced daily profile of energy expenditure in genetically obese diabetic rats'. Together they form a unique fingerprint.

Cite this