A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients

Shinichi Honda, Tomohiro Nakao, Hiroshi Mitsuyasu, Kayo Okada, Leo Gotoh, Mayumi Tomita, Hirokuni Sanematsu, Keitaro Murayama, Keisuke Ikari, Masumi Kuwano, Takashi Yoshiura, Hiroaki Kawasaki, Shigenobu Kanba

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Clinical and pharmacological studies of obsessive-compulsive disorder (OCD) have suggested that the serotonergic systems are involved in the pathogenesis, while structural imaging studies have found some neuroanatomical abnormalities in OCD patients. In the etiopathogenesis of OCD, few studies have performed concurrent assessment of genetic and neuroanatomical variables. Methods: We carried out a two-way ANOVA between a variable number of tandem repeat polymorphisms (5-HTTLPR) in the serotonin transporter gene and gray matter (GM) volumes in 40 OCD patients and 40 healthy controls (HCs). Results: We found that relative to the HCs, the OCD patients showed significant decreased GM volume in the right hippocampus, and increased GM volume in the left precentral gyrus. 5-HTTLPR polymorphism in OCD patients had a statistical tendency of stronger effects on the right frontal pole than those in HCs. Conclusions: Our results showed that the neuroanatomical changes of specific GM regions could be endophenotypes of 5-HTTLPR polymorphism in OCD.

Original languageEnglish
Article number2
JournalAnnals of General Psychiatry
Volume16
Issue number1
DOIs
Publication statusPublished - Jan 17 2017

Fingerprint

Obsessive-Compulsive Disorder
Endophenotypes
Serotonin Plasma Membrane Transport Proteins
Minisatellite Repeats
Frontal Lobe
Hippocampus
Analysis of Variance
Pharmacology
Gray Matter
Genes

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients. / Honda, Shinichi; Nakao, Tomohiro; Mitsuyasu, Hiroshi; Okada, Kayo; Gotoh, Leo; Tomita, Mayumi; Sanematsu, Hirokuni; Murayama, Keitaro; Ikari, Keisuke; Kuwano, Masumi; Yoshiura, Takashi; Kawasaki, Hiroaki; Kanba, Shigenobu.

In: Annals of General Psychiatry, Vol. 16, No. 1, 2, 17.01.2017.

Research output: Contribution to journalArticle

Honda, S, Nakao, T, Mitsuyasu, H, Okada, K, Gotoh, L, Tomita, M, Sanematsu, H, Murayama, K, Ikari, K, Kuwano, M, Yoshiura, T, Kawasaki, H & Kanba, S 2017, 'A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients', Annals of General Psychiatry, vol. 16, no. 1, 2. https://doi.org/10.1186/s12991-017-0126-6
Honda, Shinichi ; Nakao, Tomohiro ; Mitsuyasu, Hiroshi ; Okada, Kayo ; Gotoh, Leo ; Tomita, Mayumi ; Sanematsu, Hirokuni ; Murayama, Keitaro ; Ikari, Keisuke ; Kuwano, Masumi ; Yoshiura, Takashi ; Kawasaki, Hiroaki ; Kanba, Shigenobu. / A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients. In: Annals of General Psychiatry. 2017 ; Vol. 16, No. 1.
@article{2d284a562b594353a6c53572e8e4c5ee,
title = "A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients",
abstract = "Background: Clinical and pharmacological studies of obsessive-compulsive disorder (OCD) have suggested that the serotonergic systems are involved in the pathogenesis, while structural imaging studies have found some neuroanatomical abnormalities in OCD patients. In the etiopathogenesis of OCD, few studies have performed concurrent assessment of genetic and neuroanatomical variables. Methods: We carried out a two-way ANOVA between a variable number of tandem repeat polymorphisms (5-HTTLPR) in the serotonin transporter gene and gray matter (GM) volumes in 40 OCD patients and 40 healthy controls (HCs). Results: We found that relative to the HCs, the OCD patients showed significant decreased GM volume in the right hippocampus, and increased GM volume in the left precentral gyrus. 5-HTTLPR polymorphism in OCD patients had a statistical tendency of stronger effects on the right frontal pole than those in HCs. Conclusions: Our results showed that the neuroanatomical changes of specific GM regions could be endophenotypes of 5-HTTLPR polymorphism in OCD.",
author = "Shinichi Honda and Tomohiro Nakao and Hiroshi Mitsuyasu and Kayo Okada and Leo Gotoh and Mayumi Tomita and Hirokuni Sanematsu and Keitaro Murayama and Keisuke Ikari and Masumi Kuwano and Takashi Yoshiura and Hiroaki Kawasaki and Shigenobu Kanba",
year = "2017",
month = "1",
day = "17",
doi = "10.1186/s12991-017-0126-6",
language = "English",
volume = "16",
journal = "Annals of General Psychiatry",
issn = "1744-859X",
publisher = "BioMed Central",
number = "1",

}

TY - JOUR

T1 - A pilot study exploring the association of morphological changes with 5-HTTLPR polymorphism in OCD patients

AU - Honda, Shinichi

AU - Nakao, Tomohiro

AU - Mitsuyasu, Hiroshi

AU - Okada, Kayo

AU - Gotoh, Leo

AU - Tomita, Mayumi

AU - Sanematsu, Hirokuni

AU - Murayama, Keitaro

AU - Ikari, Keisuke

AU - Kuwano, Masumi

AU - Yoshiura, Takashi

AU - Kawasaki, Hiroaki

AU - Kanba, Shigenobu

PY - 2017/1/17

Y1 - 2017/1/17

N2 - Background: Clinical and pharmacological studies of obsessive-compulsive disorder (OCD) have suggested that the serotonergic systems are involved in the pathogenesis, while structural imaging studies have found some neuroanatomical abnormalities in OCD patients. In the etiopathogenesis of OCD, few studies have performed concurrent assessment of genetic and neuroanatomical variables. Methods: We carried out a two-way ANOVA between a variable number of tandem repeat polymorphisms (5-HTTLPR) in the serotonin transporter gene and gray matter (GM) volumes in 40 OCD patients and 40 healthy controls (HCs). Results: We found that relative to the HCs, the OCD patients showed significant decreased GM volume in the right hippocampus, and increased GM volume in the left precentral gyrus. 5-HTTLPR polymorphism in OCD patients had a statistical tendency of stronger effects on the right frontal pole than those in HCs. Conclusions: Our results showed that the neuroanatomical changes of specific GM regions could be endophenotypes of 5-HTTLPR polymorphism in OCD.

AB - Background: Clinical and pharmacological studies of obsessive-compulsive disorder (OCD) have suggested that the serotonergic systems are involved in the pathogenesis, while structural imaging studies have found some neuroanatomical abnormalities in OCD patients. In the etiopathogenesis of OCD, few studies have performed concurrent assessment of genetic and neuroanatomical variables. Methods: We carried out a two-way ANOVA between a variable number of tandem repeat polymorphisms (5-HTTLPR) in the serotonin transporter gene and gray matter (GM) volumes in 40 OCD patients and 40 healthy controls (HCs). Results: We found that relative to the HCs, the OCD patients showed significant decreased GM volume in the right hippocampus, and increased GM volume in the left precentral gyrus. 5-HTTLPR polymorphism in OCD patients had a statistical tendency of stronger effects on the right frontal pole than those in HCs. Conclusions: Our results showed that the neuroanatomical changes of specific GM regions could be endophenotypes of 5-HTTLPR polymorphism in OCD.

UR - http://www.scopus.com/inward/record.url?scp=85012079656&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85012079656&partnerID=8YFLogxK

U2 - 10.1186/s12991-017-0126-6

DO - 10.1186/s12991-017-0126-6

M3 - Article

AN - SCOPUS:85012079656

VL - 16

JO - Annals of General Psychiatry

JF - Annals of General Psychiatry

SN - 1744-859X

IS - 1

M1 - 2

ER -