A platform for designing hyperpolarized magnetic resonance chemical probes

Hiroshi Nonaka, Ryunosuke Hata, Tomohiro Doura, Tatsuya Nishihara, Keiko Kumagai, Mai Akakabe, Masashi Tsuda, Kazuhiro Ichikawa, Shinsuke Sando

    Research output: Contribution to journalArticle

    46 Citations (Scopus)

    Abstract

    Hyperpolarization is a highly promising technique for improving the sensitivity of magnetic resonance chemical probes. Here we report [ 15N, D9]trimethylphenylammonium as a platform for designing a variety of hyperpolarized magnetic resonance chemical probes. The platform structure shows a remarkably long 15N spin-lattice relaxation value (816 s, 14.1 T) for retaining its hyperpolarized spin state. The extended lifetime enables the detection of the hyperpolarized 15N signal of the platform for several tens of minutes and thus overcomes the intrinsic short analysis time of hyperpolarized probes. Versatility of the platform is demonstrated by applying it to three types of hyperpolarized chemical probes: one each for sensing calcium ions, reactive oxygen species (hydrogen peroxide) and enzyme activity (carboxyl esterase). All of the designed probes achieve high sensitivity with rapid reactions and chemical shift changes, which are sufficient to allow sensitive and real-time monitoring of target molecules by 15N magnetic resonance.

    Original languageEnglish
    Article number2411
    JournalNature communications
    Volume4
    DOIs
    Publication statusPublished - Dec 1 2013

    Fingerprint

    Magnetic resonance
    magnetic resonance
    Magnetic Resonance Spectroscopy
    platforms
    probes
    Esterases
    Hydrogen Peroxide
    Reactive Oxygen Species
    enzyme activity
    Spin-lattice relaxation
    Ions
    sensitivity
    Calcium
    Chemical shift
    Enzyme activity
    versatility
    retaining
    hydrogen peroxide
    spin-lattice relaxation
    chemical equilibrium

    All Science Journal Classification (ASJC) codes

    • Chemistry(all)
    • Biochemistry, Genetics and Molecular Biology(all)
    • Physics and Astronomy(all)

    Cite this

    Nonaka, H., Hata, R., Doura, T., Nishihara, T., Kumagai, K., Akakabe, M., ... Sando, S. (2013). A platform for designing hyperpolarized magnetic resonance chemical probes. Nature communications, 4, [2411]. https://doi.org/10.1038/ncomms3411

    A platform for designing hyperpolarized magnetic resonance chemical probes. / Nonaka, Hiroshi; Hata, Ryunosuke; Doura, Tomohiro; Nishihara, Tatsuya; Kumagai, Keiko; Akakabe, Mai; Tsuda, Masashi; Ichikawa, Kazuhiro; Sando, Shinsuke.

    In: Nature communications, Vol. 4, 2411, 01.12.2013.

    Research output: Contribution to journalArticle

    Nonaka, H, Hata, R, Doura, T, Nishihara, T, Kumagai, K, Akakabe, M, Tsuda, M, Ichikawa, K & Sando, S 2013, 'A platform for designing hyperpolarized magnetic resonance chemical probes', Nature communications, vol. 4, 2411. https://doi.org/10.1038/ncomms3411
    Nonaka H, Hata R, Doura T, Nishihara T, Kumagai K, Akakabe M et al. A platform for designing hyperpolarized magnetic resonance chemical probes. Nature communications. 2013 Dec 1;4. 2411. https://doi.org/10.1038/ncomms3411
    Nonaka, Hiroshi ; Hata, Ryunosuke ; Doura, Tomohiro ; Nishihara, Tatsuya ; Kumagai, Keiko ; Akakabe, Mai ; Tsuda, Masashi ; Ichikawa, Kazuhiro ; Sando, Shinsuke. / A platform for designing hyperpolarized magnetic resonance chemical probes. In: Nature communications. 2013 ; Vol. 4.
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