A potent alpha-glucosidase inhibitor from Myristica cinnamomea King

Yasodha Sivasothy, Kong Yong Loo, Kok Hoong Leong, Marc Litaudon, Khalijah Awang

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

A dimeric acylphenol and a potent α-glucosidase inhibitor, giganteone D (IC50 5.05 μM), was isolated and characterized from the bark of Myristica cinnamomea King. The bark also yielded an acylphenol with an unprecedented skeleton for which the name cinnamomeone A (IC50 358.80 μM) was proposed. Their structures were established by means of NMR and MS spectrometric analyses. The Lineweaver-Burk plot of giganteone D indicated that it was a mixed-type inhibitor. This is the first report on the α-glucosidase inhibiting potential of acylphenols.

Original languageEnglish
Pages (from-to)265-269
Number of pages5
JournalPhytochemistry
Volume122
DOIs
Publication statusPublished - Feb 1 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Plant Science
  • Horticulture

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