A potent alpha-glucosidase inhibitor from Myristica cinnamomea King

Yasodha Sivasothy; Kong Yong Loo; Kok Hoong Leong; Marc Litaudon; Khalijah Awang

doi:10.1016/j.phytochem.2015.12.007

A potent alpha-glucosidase inhibitor from Myristica cinnamomea King

Yasodha Sivasothy, Kong Yong Loo, Kok Hoong Leong, Marc Litaudon, Khalijah Awang

Research output: Contribution to journal › Article › peer-review

32 Citations (Scopus)

Abstract

A dimeric acylphenol and a potent α-glucosidase inhibitor, giganteone D (IC₅₀ 5.05 μM), was isolated and characterized from the bark of Myristica cinnamomea King. The bark also yielded an acylphenol with an unprecedented skeleton for which the name cinnamomeone A (IC₅₀ 358.80 μM) was proposed. Their structures were established by means of NMR and MS spectrometric analyses. The Lineweaver-Burk plot of giganteone D indicated that it was a mixed-type inhibitor. This is the first report on the α-glucosidase inhibiting potential of acylphenols.

Original language	English
Pages (from-to)	265-269
Number of pages	5
Journal	Phytochemistry
Volume	122
DOIs	https://doi.org/10.1016/j.phytochem.2015.12.007
Publication status	Published - Feb 1 2016
Externally published	Yes

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Plant Science
Horticulture

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10.1016/j.phytochem.2015.12.007

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title = "A potent alpha-glucosidase inhibitor from Myristica cinnamomea King",

abstract = "A dimeric acylphenol and a potent α-glucosidase inhibitor, giganteone D (IC50 5.05 μM), was isolated and characterized from the bark of Myristica cinnamomea King. The bark also yielded an acylphenol with an unprecedented skeleton for which the name cinnamomeone A (IC50 358.80 μM) was proposed. Their structures were established by means of NMR and MS spectrometric analyses. The Lineweaver-Burk plot of giganteone D indicated that it was a mixed-type inhibitor. This is the first report on the α-glucosidase inhibiting potential of acylphenols.",

author = "Yasodha Sivasothy and Loo, {Kong Yong} and Leong, {Kok Hoong} and Marc Litaudon and Khalijah Awang",

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doi = "10.1016/j.phytochem.2015.12.007",

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AU - Sivasothy, Yasodha

AU - Loo, Kong Yong

AU - Leong, Kok Hoong

AU - Litaudon, Marc

AU - Awang, Khalijah

N1 - Funding Information: The authors acknowledge the University of Malaya for providing the University Research Grants RP001-2012 and BK002-2015 , which have made this work possible. Publisher Copyright: © 2015 Elsevier Ltd. All rights reserved.

PY - 2016/2/1

Y1 - 2016/2/1

N2 - A dimeric acylphenol and a potent α-glucosidase inhibitor, giganteone D (IC50 5.05 μM), was isolated and characterized from the bark of Myristica cinnamomea King. The bark also yielded an acylphenol with an unprecedented skeleton for which the name cinnamomeone A (IC50 358.80 μM) was proposed. Their structures were established by means of NMR and MS spectrometric analyses. The Lineweaver-Burk plot of giganteone D indicated that it was a mixed-type inhibitor. This is the first report on the α-glucosidase inhibiting potential of acylphenols.

AB - A dimeric acylphenol and a potent α-glucosidase inhibitor, giganteone D (IC50 5.05 μM), was isolated and characterized from the bark of Myristica cinnamomea King. The bark also yielded an acylphenol with an unprecedented skeleton for which the name cinnamomeone A (IC50 358.80 μM) was proposed. Their structures were established by means of NMR and MS spectrometric analyses. The Lineweaver-Burk plot of giganteone D indicated that it was a mixed-type inhibitor. This is the first report on the α-glucosidase inhibiting potential of acylphenols.

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JF - Phytochemistry

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A potent alpha-glucosidase inhibitor from Myristica cinnamomea King

Abstract

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