A potential improvement of rheumatoid arthritis in a patient treated with liraglutide for glucocorticoid-induced diabetes

Michiko Kohno, Masatoshi Nomura, Ichiro Abe, Yusuke Matsumura, Yayoi Matsuda, Masahiro Adachi, Hisaya Kawate, Keizo Ohnaka, Takahiko Horiuchi, Ryoichi Takayanagi

Research output: Contribution to journalArticlepeer-review

Abstract

A 74-year-old male, who had been prescribed prednisolone (PSL) for rheumatoid arthritis (RA) since age 63 and who had developed glucocorticoid-induced diabetes at age 69, was hospitalized due to poor glycemic control. On admission, he was taking 7.5 mg/day of PSL and his Hb Ale was 8.1 % despite infusion of 27 U/day of insulin. As preserved β-cell function was confirmed by a glucagon challenge test, liraglutide therapy was introduced. A stepwise increase in liraglutide successfully improved his glucose tolerance and led to discontinuation of insulin treatment A good glycemic control was finally achieved by the combination of 0.9 mg/day of liraglutide and 3 mg/day of glimepiride. Interestingly, the level of matrix metalloproteinase-3, which indicates the RA activity, was dramatically reduced from 356 ng/m/to 187 ng/m/in parallel with this treatment. The present case may imply that there is a correlation between the administration of glucagon-like peptide-1 and an improvement in the symptoms associated with rheumatoid arthritis.

Original languageEnglish
Pages (from-to)179-184
Number of pages6
JournalJournal of the Japan Diabetes Society
Volume56
Issue number3
Publication statusPublished - Mar 2013

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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