A preliminary study of the effect of DBD plasma and osmolytes on T98G brain cancer and HEK non-malignant cells

Nagendra Kumar Kaushik; Pankaj Attri; Neha Kaushik; Eun Ha Choi

doi:10.3390/molecules18054917

A preliminary study of the effect of DBD plasma and osmolytes on T98G brain cancer and HEK non-malignant cells

Nagendra Kumar Kaushik, Pankaj Attri, Neha Kaushik, Eun Ha Choi

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Non-thermal plasmas are emerging as a novel tool for the treatment of living tissues for biological and medical purpose. In this study, we described the effect of 4 min dielectric barrier discharge (DBD) plasma on both T98G cancer and HEK normal cell lines in the presence of different concentrations of osmolytes. This treatment strategy shows a specific inhibitory effect of a 240 s plasma exposure in the presence of osmolytes against T98G brain cancer cells only, but not on HEK normal cells. Based on these interesting properties of osmolytes, a non-thermal plasma appears to be a potential anticancer treatment strategy for different kinds of cancers in the presence of osmolytes.

Original language	English
Pages (from-to)	4917-4928
Number of pages	12
Journal	Molecules
Volume	18
Issue number	5
DOIs	https://doi.org/10.3390/molecules18054917
Publication status	Published - May 2013
Externally published	Yes

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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A preliminary study of the effect of DBD plasma and osmolytes on T98G brain cancer and HEK non-malignant cells

Abstract

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