A preliminary study of the effect of DBD plasma and osmolytes on T98G brain cancer and HEK non-malignant cells

Nagendra Kumar Kaushik, Pankaj Attri, Neha Kaushik, Eun Ha Choi

Research output: Contribution to journalArticlepeer-review

40 Citations (Scopus)

Abstract

Non-thermal plasmas are emerging as a novel tool for the treatment of living tissues for biological and medical purpose. In this study, we described the effect of 4 min dielectric barrier discharge (DBD) plasma on both T98G cancer and HEK normal cell lines in the presence of different concentrations of osmolytes. This treatment strategy shows a specific inhibitory effect of a 240 s plasma exposure in the presence of osmolytes against T98G brain cancer cells only, but not on HEK normal cells. Based on these interesting properties of osmolytes, a non-thermal plasma appears to be a potential anticancer treatment strategy for different kinds of cancers in the presence of osmolytes.

Original languageEnglish
Pages (from-to)4917-4928
Number of pages12
JournalMolecules
Volume18
Issue number5
DOIs
Publication statusPublished - May 2013
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'A preliminary study of the effect of DBD plasma and osmolytes on T98G brain cancer and HEK non-malignant cells'. Together they form a unique fingerprint.

Cite this