TY - JOUR
T1 - A pro-con debate
T2 - Current controversies in pah pathogenesis at the american thoracic society international conference in 2017
AU - Kuebler, Wolfgang M.
AU - Nicolls, Mark R.
AU - Olschewski, Andrea
AU - Abe, Kohtaro
AU - Rabinovitch, Marlene
AU - Stewart, Duncan
AU - Chan, Stephen Y.
AU - Morrell, Nicholas W.
AU - Archer, Stephen L.
AU - Spiekerkoetter, Edda
N1 - Funding Information:
Support for this work was provided by the following: Heart and Stroke Foundation of Canada (Grant G-16-00013171), Deutsche Forschungsgesell-schaft (Grant KU1218/9-1), Deutsche Zentrum für Herz-Kreislauf-Forschung e. V., Deutsches Zentrum fuer Lungenforschung, and Ontario Research Excellence Fund SCORR (Grant RE07-086; to W. M. Kuebler); National Heart, Lung, and Blood Institute (NHLBI; Grants HL122887, HL014985, HL125739, HL120001, and HL138473; to M. R. Nicolls); Oesterreichische Nationalbank (Grant 16682), Oesterreichischer Auslandsdienst fuer Wissenschaftlich-Tech-nische Zusammenarbeit (Grant Hu07/2016), and International Ph.D. Program University of Graz (to A. Olschewski); Grants-in-Aid for Scientific Research from the Japan Society for the Promotion Science (26461146 and 17K09591; to K. Abe); NHLBI (Grants R01 HL074186, R01 HL087118, R01 HL122887, R01 HL138473, P01 HL108797, R24 HL123767, and K12 HL120001; to M. Rabinovitch); NHLBI (Grants R01 HL124021, HL122596, and HL138437), National Center for Advancing Translational Sciences (Grant UH2 TR00-2073), and American Heart Association Established Investigator Award (18EIA33900027; to S. Y. Chan); Canadian Institutes of Health Research (CIHR) Foundation Award (FDN_143291) and Ontario Research Excellence Fund (ORF RE07-086; to D. Stewart); British Heart Foundation Chair of Cardiopulmonary Medicine (to N. W. Morrell); CIHR Foundation, NHLBI (Grants RO1-HL071115 and 1RC1HL099462), Tier 1 Canada Research Chair in Mitochondrial Dynamics, William J. Henderson Foundation, CIHR Vascular Network, and Canadian Vascular Network (to S. L. Archer); and NHLBI (Grant R01 HL128734), Department of Defense (Grant PR161256), Wall Center for Pulmonary Vascular Disease Stanford, and Pulmonary Hypertension Association Career Development Grant (to E. Spiekerkoetter).
Funding Information:
Dr. S. L. Archer thanks Dr. William Nichols for providing preliminary data from the National Heart, Lung, and Blood Institute PAH Biobank at Cincinnati Children’s Hospital Medical Center as to the prevalence of gene mutations in PAH. Elements of illustration were used from Servier Medical Art and modified under a Creative Common Attribution 3.0 Generic License (https:// smart.servier.com/). GRANTS Support for this work was provided by the following: Heart and Stroke Foundation of Canada (Grant G-16-00013171), Deutsche Forschungsgesell-schaft (Grant KU1218/9-1), Deutsche Zentrum für Herz-Kreislauf-Forschung e. V., Deutsches Zentrum fuer Lungenforschung, and Ontario Research Excellence Fund SCORR (Grant RE07-086; to W. M. Kuebler); National Heart, Lung, and Blood Institute (NHLBI; Grants HL122887, HL014985, HL125739, HL120001, and HL138473; to M. R. Nicolls); Oesterreichische Nationalbank (Grant 16682), Oesterreichischer Auslandsdienst fuer Wissenschaftlich-Tech-nische Zusammenarbeit (Grant Hu07/2016), and International Ph.D. Program University of Graz (to A. Olschewski); Grants-in-Aid for Scientific Research from the Japan Society for the Promotion Science (26461146 and 17K09591; to K. Abe); NHLBI (Grants R01 HL074186, R01 HL087118, R01 HL122887, R01 HL138473, P01 HL108797, R24 HL123767, and K12 HL120001; to M. Rabinovitch); NHLBI (Grants R01 HL124021, HL122596, and HL138437), National Center for Advancing Translational Sciences (Grant UH2 TR00-2073), and American Heart Association Established Investigator Award (18EIA33900027; to S. Y. Chan); Canadian Institutes of Health Research (CIHR) Foundation Award (FDN_143291) and Ontario Research Excellence Fund (ORF RE07-086; to D. Stewart); British Heart Foundation Chair of Cardiopulmonary Medicine (to N. W. Morrell); CIHR Foundation, NHLBI (Grants RO1-HL071115 and 1RC1HL099462), Tier 1 Canada Research Chair in Mitochondrial Dynamics, William J. Henderson Foundation, CIHR Vascular Network, and Canadian Vascular Network (to S. L. Archer); and NHLBI (Grant R01 HL128734), Department of Defense (Grant PR161256), Wall Center for Pulmonary Vascular Disease Stanford, and Pulmonary Hypertension Association Career Development Grant (to E. Spiekerkoetter).
Publisher Copyright:
© 2018 American Physiological Society. All rights reserved.
PY - 2018/10
Y1 - 2018/10
N2 - The following review summarizes the pro-con debate about current controversies regarding the pathogenesis of pulmonary arterial hypertension (PAH) that took place at the American Thoracic Society Conference in May 2017. Leaders in the field of PAH research discussed the importance of the immune system, the role of hemodynamic stress and endothelial apoptosis, as well as bone morphogenetic protein receptor-2 signaling in PAH pathogenesis. Whereas this summary does not intend to resolve obvious conflicts in opinion, we hope that the presented arguments entice further discussions and draw a new generation of enthusiastic researchers into this vibrant field of science to bridge existing gaps for a better understanding and therapy of this fatal disease.
AB - The following review summarizes the pro-con debate about current controversies regarding the pathogenesis of pulmonary arterial hypertension (PAH) that took place at the American Thoracic Society Conference in May 2017. Leaders in the field of PAH research discussed the importance of the immune system, the role of hemodynamic stress and endothelial apoptosis, as well as bone morphogenetic protein receptor-2 signaling in PAH pathogenesis. Whereas this summary does not intend to resolve obvious conflicts in opinion, we hope that the presented arguments entice further discussions and draw a new generation of enthusiastic researchers into this vibrant field of science to bridge existing gaps for a better understanding and therapy of this fatal disease.
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UR - http://www.scopus.com/inward/citedby.url?scp=85054914096&partnerID=8YFLogxK
U2 - 10.1152/ajplung.00150.2018
DO - 10.1152/ajplung.00150.2018
M3 - Review article
C2 - 29877097
AN - SCOPUS:85054914096
SN - 1040-0605
VL - 315
SP - L502-L516
JO - American Journal of Physiology
JF - American Journal of Physiology
IS - 4
ER -