A pro-con debate

Current controversies in pah pathogenesis at the american thoracic society international conference in 2017

Wolfgang M. Kuebler, Mark R. Nicolls, Andrea Olschewski, Kotaro Abe, Marlene Rabinovitch, Duncan Stewart, Stephen Y. Chan, Nicholas W. Morrell, Stephen L. Archer, Edda Spiekerkoetter

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

The following review summarizes the pro-con debate about current controversies regarding the pathogenesis of pulmonary arterial hypertension (PAH) that took place at the American Thoracic Society Conference in May 2017. Leaders in the field of PAH research discussed the importance of the immune system, the role of hemodynamic stress and endothelial apoptosis, as well as bone morphogenetic protein receptor-2 signaling in PAH pathogenesis. Whereas this summary does not intend to resolve obvious conflicts in opinion, we hope that the presented arguments entice further discussions and draw a new generation of enthusiastic researchers into this vibrant field of science to bridge existing gaps for a better understanding and therapy of this fatal disease.

Original languageEnglish
Pages (from-to)L502-L516
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume315
Issue number4
DOIs
Publication statusPublished - Oct 1 2018

Fingerprint

Pulmonary Hypertension
Thorax
Bone Morphogenetic Protein Receptors
Bone Morphogenetic Protein 2
Immune System
Hemodynamics
Research Personnel
Apoptosis
Research
Therapeutics

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology

Cite this

A pro-con debate : Current controversies in pah pathogenesis at the american thoracic society international conference in 2017. / Kuebler, Wolfgang M.; Nicolls, Mark R.; Olschewski, Andrea; Abe, Kotaro; Rabinovitch, Marlene; Stewart, Duncan; Chan, Stephen Y.; Morrell, Nicholas W.; Archer, Stephen L.; Spiekerkoetter, Edda.

In: American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 315, No. 4, 01.10.2018, p. L502-L516.

Research output: Contribution to journalReview article

Kuebler, WM, Nicolls, MR, Olschewski, A, Abe, K, Rabinovitch, M, Stewart, D, Chan, SY, Morrell, NW, Archer, SL & Spiekerkoetter, E 2018, 'A pro-con debate: Current controversies in pah pathogenesis at the american thoracic society international conference in 2017', American Journal of Physiology - Lung Cellular and Molecular Physiology, vol. 315, no. 4, pp. L502-L516. https://doi.org/10.1152/ajplung.00150.2018
Kuebler, Wolfgang M. ; Nicolls, Mark R. ; Olschewski, Andrea ; Abe, Kotaro ; Rabinovitch, Marlene ; Stewart, Duncan ; Chan, Stephen Y. ; Morrell, Nicholas W. ; Archer, Stephen L. ; Spiekerkoetter, Edda. / A pro-con debate : Current controversies in pah pathogenesis at the american thoracic society international conference in 2017. In: American Journal of Physiology - Lung Cellular and Molecular Physiology. 2018 ; Vol. 315, No. 4. pp. L502-L516.
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