A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population

The Hisayama study

Kentaro Shikata, Yutaka Kiyohara, Michiaki Kubo, Koji Yonemoto, Toshiharu Ninomiya, Tomoko Shirota, Yumihiro Tanizaki, Yasufumi Doi, Keiichi Tanaka, Yoshinori Oishi, Takayuki Matsumoto, Mitsuo Iida

Research output: Contribution to journalArticle

156 Citations (Scopus)

Abstract

The results of prospective studies of the association between dietary salt intake and gastric cancer occurrence remain controversial. To examine this issue in a cohort study of a general population, 2,476 subjects aged 40 years or older were stratified into 4 groups according to the amount of daily salt intake: namely, <10.0,10.0-12.9,13.0-15.9, and ≥ 16.0 per day and were followed up prospectively for 14 years. During the follow-up period, 93 subjects developed gastric cancer. The age- and sex-adjusted incidence was significantly higher in the second to fourth groups than in the first group (age- and sex-adjusted hazard ratio [95% confidence interval], 2.42 [1.24-4.71] for the second group; 2.10 [1.03-4.30] for the third group; 2.98 [1.53-5.82] for the fourth group). This association remained substantially unchanged even after adjusting for other confounding factors such as age, sex, Helicobacter pylori infection, atrophic gastritis, medical history of peptic ulcer, family history of cancer, body mass index, diabetes, total cholesterol, physical activity, alcohol intake, smoking habit and other dietary factors. In the stratified analysis, a significant salt-cancer association was observed only in subjects who had both Helicobacter pylori infection and atrophic gastritis (age- and sex-adjusted hazard ratio, 2.87 [1.14-7.24]). Our findings suggest that high dietary salt intake is a significant risk factor for gastric cancer; moreover, this association was found to be strong in the presence of Helicobacter pylori infection with atrophic gastritis.

Original languageEnglish
Pages (from-to)196-201
Number of pages6
JournalInternational Journal of Cancer
Volume119
Issue number1
DOIs
Publication statusPublished - Jul 1 2006

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Atrophic Gastritis
Stomach Neoplasms
Helicobacter Infections
Salts
Helicobacter pylori
Prospective Studies
Incidence
Population
Feeding Behavior
Peptic Ulcer
Neoplasms
Body Mass Index
Cohort Studies
Age Groups
Smoking
Cholesterol
Alcohols
Confidence Intervals
Exercise

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population : The Hisayama study. / Shikata, Kentaro; Kiyohara, Yutaka; Kubo, Michiaki; Yonemoto, Koji; Ninomiya, Toshiharu; Shirota, Tomoko; Tanizaki, Yumihiro; Doi, Yasufumi; Tanaka, Keiichi; Oishi, Yoshinori; Matsumoto, Takayuki; Iida, Mitsuo.

In: International Journal of Cancer, Vol. 119, No. 1, 01.07.2006, p. 196-201.

Research output: Contribution to journalArticle

Shikata, K, Kiyohara, Y, Kubo, M, Yonemoto, K, Ninomiya, T, Shirota, T, Tanizaki, Y, Doi, Y, Tanaka, K, Oishi, Y, Matsumoto, T & Iida, M 2006, 'A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population: The Hisayama study', International Journal of Cancer, vol. 119, no. 1, pp. 196-201. https://doi.org/10.1002/ijc.21822
Shikata, Kentaro ; Kiyohara, Yutaka ; Kubo, Michiaki ; Yonemoto, Koji ; Ninomiya, Toshiharu ; Shirota, Tomoko ; Tanizaki, Yumihiro ; Doi, Yasufumi ; Tanaka, Keiichi ; Oishi, Yoshinori ; Matsumoto, Takayuki ; Iida, Mitsuo. / A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population : The Hisayama study. In: International Journal of Cancer. 2006 ; Vol. 119, No. 1. pp. 196-201.
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