A protective role of γδ T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice

J. Usami, K. Hiromatsu, Y. Matsumoto, K. Maeda, H. Inagaki, T. Suzuki, Yasunobu Yoshikai

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    10 Citations (Scopus)

    Abstract

    We investigated the host defense mechanism in primary infection with Listeria monocytogenes in non-obese diabetic (NOD) mice at pre-diabetic stage showing an impaired responsiveness of the αβ T cells to T-cell receptor (TCR) triggering. The NOD mice showed a deteriorated resistance at the late stage after an intraperitoneal infection with L. monocytogenes compared with BALB/c and C57BL/6 mice as assessed by bacterial growth in organs. Consistent with our previous findings, a prominent increase in number of γδ T cells was evident at the early stage after infection, while generation of Listeria-specific αβ T cells was impaired in these mice. In vivo administration of anti-TCR γδ monoclonal antibody (mAb) allowed L. monocytogenes to grow exaggeratedly in the NOD mice. These results imply that γδ T cells may be mainly involved in protection against primary infection with L. monocytogenes in NOD mice.

    Original languageEnglish
    Pages (from-to)199-205
    Number of pages7
    JournalImmunology
    Volume86
    Issue number2
    Publication statusPublished - Jan 1 1995

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

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