A protective role of γδ T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice

J. Usami, K. Hiromatsu, Y. Matsumoto, K. Maeda, H. Inagaki, T. Suzuki, Yasunobu Yoshikai

    Research output: Contribution to journalArticle

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    Abstract

    We investigated the host defense mechanism in primary infection with Listeria monocytogenes in non-obese diabetic (NOD) mice at pre-diabetic stage showing an impaired responsiveness of the αβ T cells to T-cell receptor (TCR) triggering. The NOD mice showed a deteriorated resistance at the late stage after an intraperitoneal infection with L. monocytogenes compared with BALB/c and C57BL/6 mice as assessed by bacterial growth in organs. Consistent with our previous findings, a prominent increase in number of γδ T cells was evident at the early stage after infection, while generation of Listeria-specific αβ T cells was impaired in these mice. In vivo administration of anti-TCR γδ monoclonal antibody (mAb) allowed L. monocytogenes to grow exaggeratedly in the NOD mice. These results imply that γδ T cells may be mainly involved in protection against primary infection with L. monocytogenes in NOD mice.

    Original languageEnglish
    Pages (from-to)199-205
    Number of pages7
    JournalImmunology
    Volume86
    Issue number2
    Publication statusPublished - Jan 1 1995

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    Inbred NOD Mouse
    Listeria monocytogenes
    T-Lymphocytes
    T-Cell Antigen Receptor
    Infection
    Listeria
    Inbred C57BL Mouse
    Monoclonal Antibodies
    Growth

    All Science Journal Classification (ASJC) codes

    • Immunology and Allergy
    • Immunology

    Cite this

    Usami, J., Hiromatsu, K., Matsumoto, Y., Maeda, K., Inagaki, H., Suzuki, T., & Yoshikai, Y. (1995). A protective role of γδ T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice. Immunology, 86(2), 199-205.

    A protective role of γδ T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice. / Usami, J.; Hiromatsu, K.; Matsumoto, Y.; Maeda, K.; Inagaki, H.; Suzuki, T.; Yoshikai, Yasunobu.

    In: Immunology, Vol. 86, No. 2, 01.01.1995, p. 199-205.

    Research output: Contribution to journalArticle

    Usami, J, Hiromatsu, K, Matsumoto, Y, Maeda, K, Inagaki, H, Suzuki, T & Yoshikai, Y 1995, 'A protective role of γδ T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice', Immunology, vol. 86, no. 2, pp. 199-205.
    Usami J, Hiromatsu K, Matsumoto Y, Maeda K, Inagaki H, Suzuki T et al. A protective role of γδ T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice. Immunology. 1995 Jan 1;86(2):199-205.
    Usami, J. ; Hiromatsu, K. ; Matsumoto, Y. ; Maeda, K. ; Inagaki, H. ; Suzuki, T. ; Yoshikai, Yasunobu. / A protective role of γδ T cells in primary infection with Listeria monocytogenes in autoimmune non-obese diabetic mice. In: Immunology. 1995 ; Vol. 86, No. 2. pp. 199-205.
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