A protein kinase signal-responsive gene carrier modified RGD peptide

Jun Oishi, Moeko Ijuin, Tatsuhiko Sonoda, Jeong Hun Kang, Kenji Kawamura, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

    Research output: Contribution to journalArticlepeer-review

    18 Citations (Scopus)

    Abstract

    We have previously reported artificial gene-regulation systems responding to cyclic AMP-dependent protein kinase (PKA) using a cationic polymer. However, this polymer alone cannot deliver any gene into living cells. In the present work, we modified the signal-responsive polymer to the RGD peptide for the introduction of a polymer/DNA complex into living cells and succeeded in regulating the gene expression responding to intracellular PKA activation.

    Original languageEnglish
    Pages (from-to)5740-5743
    Number of pages4
    JournalBioorganic and Medicinal Chemistry Letters
    Volume16
    Issue number22
    DOIs
    Publication statusPublished - Nov 15 2006

    All Science Journal Classification (ASJC) codes

    • Biochemistry
    • Molecular Medicine
    • Molecular Biology
    • Pharmaceutical Science
    • Drug Discovery
    • Clinical Biochemistry
    • Organic Chemistry

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