A protein kinase signal-responsive gene carrier modified RGD peptide

Jun Oishi, Moeko Ijuin, Tatsuhiko Sonoda, Jeong Hun Kang, Kenji Kawamura, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

We have previously reported artificial gene-regulation systems responding to cyclic AMP-dependent protein kinase (PKA) using a cationic polymer. However, this polymer alone cannot deliver any gene into living cells. In the present work, we modified the signal-responsive polymer to the RGD peptide for the introduction of a polymer/DNA complex into living cells and succeeded in regulating the gene expression responding to intracellular PKA activation.

Original languageEnglish
Pages (from-to)5740-5743
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number22
DOIs
Publication statusPublished - Nov 15 2006

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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