A protein kinase signal-responsive gene carrier modified RGD peptide

Jun Oishi, Moeko Ijuin, Tatsuhiko Sonoda, Jeong Hun Kang, Kenji Kawamura, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We have previously reported artificial gene-regulation systems responding to cyclic AMP-dependent protein kinase (PKA) using a cationic polymer. However, this polymer alone cannot deliver any gene into living cells. In the present work, we modified the signal-responsive polymer to the RGD peptide for the introduction of a polymer/DNA complex into living cells and succeeded in regulating the gene expression responding to intracellular PKA activation.

Original languageEnglish
Pages (from-to)5740-5743
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume16
Issue number22
DOIs
Publication statusPublished - Nov 15 2006

Fingerprint

Protein Kinases
Polymers
Genes
Gene expression
Cells
Synthetic Genes
Cyclic AMP-Dependent Protein Kinases
Chemical activation
Gene Expression
arginyl-glycyl-aspartic acid
DNA

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

A protein kinase signal-responsive gene carrier modified RGD peptide. / Oishi, Jun; Ijuin, Moeko; Sonoda, Tatsuhiko; Kang, Jeong Hun; Kawamura, Kenji; Mori, Takeshi; Niidome, Takuro; Katayama, Yoshiki.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 16, No. 22, 15.11.2006, p. 5740-5743.

Research output: Contribution to journalArticle

Oishi, Jun ; Ijuin, Moeko ; Sonoda, Tatsuhiko ; Kang, Jeong Hun ; Kawamura, Kenji ; Mori, Takeshi ; Niidome, Takuro ; Katayama, Yoshiki. / A protein kinase signal-responsive gene carrier modified RGD peptide. In: Bioorganic and Medicinal Chemistry Letters. 2006 ; Vol. 16, No. 22. pp. 5740-5743.
@article{2fc96c33b74d4c5a9ce89f1314ab2504,
title = "A protein kinase signal-responsive gene carrier modified RGD peptide",
abstract = "We have previously reported artificial gene-regulation systems responding to cyclic AMP-dependent protein kinase (PKA) using a cationic polymer. However, this polymer alone cannot deliver any gene into living cells. In the present work, we modified the signal-responsive polymer to the RGD peptide for the introduction of a polymer/DNA complex into living cells and succeeded in regulating the gene expression responding to intracellular PKA activation.",
author = "Jun Oishi and Moeko Ijuin and Tatsuhiko Sonoda and Kang, {Jeong Hun} and Kenji Kawamura and Takeshi Mori and Takuro Niidome and Yoshiki Katayama",
year = "2006",
month = "11",
day = "15",
doi = "10.1016/j.bmcl.2006.08.096",
language = "English",
volume = "16",
pages = "5740--5743",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "22",

}

TY - JOUR

T1 - A protein kinase signal-responsive gene carrier modified RGD peptide

AU - Oishi, Jun

AU - Ijuin, Moeko

AU - Sonoda, Tatsuhiko

AU - Kang, Jeong Hun

AU - Kawamura, Kenji

AU - Mori, Takeshi

AU - Niidome, Takuro

AU - Katayama, Yoshiki

PY - 2006/11/15

Y1 - 2006/11/15

N2 - We have previously reported artificial gene-regulation systems responding to cyclic AMP-dependent protein kinase (PKA) using a cationic polymer. However, this polymer alone cannot deliver any gene into living cells. In the present work, we modified the signal-responsive polymer to the RGD peptide for the introduction of a polymer/DNA complex into living cells and succeeded in regulating the gene expression responding to intracellular PKA activation.

AB - We have previously reported artificial gene-regulation systems responding to cyclic AMP-dependent protein kinase (PKA) using a cationic polymer. However, this polymer alone cannot deliver any gene into living cells. In the present work, we modified the signal-responsive polymer to the RGD peptide for the introduction of a polymer/DNA complex into living cells and succeeded in regulating the gene expression responding to intracellular PKA activation.

UR - http://www.scopus.com/inward/record.url?scp=33749256086&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33749256086&partnerID=8YFLogxK

U2 - 10.1016/j.bmcl.2006.08.096

DO - 10.1016/j.bmcl.2006.08.096

M3 - Article

C2 - 16971118

AN - SCOPUS:33749256086

VL - 16

SP - 5740

EP - 5743

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 22

ER -