A randomized phase II selection trial in patients with advanced/recurrent gastric cancer

Trial for advanced stomach cancer (TASC)

Satoshi Morita, Hideo Baba, Akira Tsuburaya, Hiroya Takiuchi, Takanori Matsui, Yoshihiko Maehara, Junichi Sakamoto

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A randomized phase II clinical trial is being conducted for patients with advanced or recurrent gastric cancer, in order to select the most promising treatment for subsequent evaluation in a large-scale phase III trial. We compare four chemotherapeutic treatments, which include two sequential and two combination regimens using paclitaxel with 5-fluorouracil or S-1, an oral fluorouracil derivative. The primary endpoint is 10-month overall survival rate, while the secondary endpoints are adverse events, time to treatment failure and progression-free survival. A Bayesian method is used to provide a statistical rule for monitoring the trial. Forty patients per treatment regimen (160 in total) were randomized into one of the four regimens using a centralized dynamic method.

Original languageEnglish
Pages (from-to)469-472
Number of pages4
JournalJapanese journal of clinical oncology
Volume37
Issue number6
DOIs
Publication statusPublished - Jun 1 2007

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Stomach Neoplasms
Fluorouracil
Phase II Clinical Trials
Bayes Theorem
Paclitaxel
Treatment Failure
Disease-Free Survival
Therapeutics
Survival Rate
Randomized Controlled Trials

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

A randomized phase II selection trial in patients with advanced/recurrent gastric cancer : Trial for advanced stomach cancer (TASC). / Morita, Satoshi; Baba, Hideo; Tsuburaya, Akira; Takiuchi, Hiroya; Matsui, Takanori; Maehara, Yoshihiko; Sakamoto, Junichi.

In: Japanese journal of clinical oncology, Vol. 37, No. 6, 01.06.2007, p. 469-472.

Research output: Contribution to journalArticle

Morita, Satoshi ; Baba, Hideo ; Tsuburaya, Akira ; Takiuchi, Hiroya ; Matsui, Takanori ; Maehara, Yoshihiko ; Sakamoto, Junichi. / A randomized phase II selection trial in patients with advanced/recurrent gastric cancer : Trial for advanced stomach cancer (TASC). In: Japanese journal of clinical oncology. 2007 ; Vol. 37, No. 6. pp. 469-472.
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