A Rare Case of 46,XX True Hermaphroditism with Hidden Mosaicism with Sex-determining Region Y Chromosome-bearing Cells in the Gonads

Hisako Inoue, Masatoshi Nomura, Toshihiko Yanase, Isao Ichino, Kiminobu Goto, Shouichiro Ikuyama, Ryouichi Takayanagi, Hajime Nawata

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The sex-determining region Y chromosome (SRY) triggers testis determination. We report a 46,XX true hermaphrodite who had ambiguous genitalia at birth. A laparotomy at one year of age revealed this patient to have a testis on the right side and an ovotestis on the left side. By polymerase chain reaction analysis no SRY was detected in the DNA from the leukocytes but it was found in the DNA from the ovotestis. The hidden mosaicism with the Y-bearing cells in the gonads is likely the cause of the dual gonads in this patient.

Original languageEnglish
Pages (from-to)467-471
Number of pages5
JournalInternal Medicine
Volume37
Issue number5
Publication statusPublished - Dec 1 1998

Fingerprint

Ovotesticular Disorders of Sex Development
Mosaicism
Y Chromosome
Gonads
Testis
Disorders of Sex Development
DNA
Laparotomy
Leukocytes
Parturition
Polymerase Chain Reaction

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Inoue, H., Nomura, M., Yanase, T., Ichino, I., Goto, K., Ikuyama, S., ... Nawata, H. (1998). A Rare Case of 46,XX True Hermaphroditism with Hidden Mosaicism with Sex-determining Region Y Chromosome-bearing Cells in the Gonads. Internal Medicine, 37(5), 467-471.

A Rare Case of 46,XX True Hermaphroditism with Hidden Mosaicism with Sex-determining Region Y Chromosome-bearing Cells in the Gonads. / Inoue, Hisako; Nomura, Masatoshi; Yanase, Toshihiko; Ichino, Isao; Goto, Kiminobu; Ikuyama, Shouichiro; Takayanagi, Ryouichi; Nawata, Hajime.

In: Internal Medicine, Vol. 37, No. 5, 01.12.1998, p. 467-471.

Research output: Contribution to journalArticle

Inoue, H, Nomura, M, Yanase, T, Ichino, I, Goto, K, Ikuyama, S, Takayanagi, R & Nawata, H 1998, 'A Rare Case of 46,XX True Hermaphroditism with Hidden Mosaicism with Sex-determining Region Y Chromosome-bearing Cells in the Gonads', Internal Medicine, vol. 37, no. 5, pp. 467-471.
Inoue, Hisako ; Nomura, Masatoshi ; Yanase, Toshihiko ; Ichino, Isao ; Goto, Kiminobu ; Ikuyama, Shouichiro ; Takayanagi, Ryouichi ; Nawata, Hajime. / A Rare Case of 46,XX True Hermaphroditism with Hidden Mosaicism with Sex-determining Region Y Chromosome-bearing Cells in the Gonads. In: Internal Medicine. 1998 ; Vol. 37, No. 5. pp. 467-471.
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