A Rare Case of Rheumatoid Arthritis with Tocilizumab-induced Intestinal Mucosal Injury

Akito Ohkubo; Takashi Osoegawa; Naohiko Harada; Yoichiro Iboshi; Yorinobu Sumida; Makoto Nakamuta; Eiichi Suematsu; Hiroyuki Kobayashi; Eikichi Ihara

doi:10.2169/internalmedicine.8031-21

A Rare Case of Rheumatoid Arthritis with Tocilizumab-induced Intestinal Mucosal Injury

Akito Ohkubo, Takashi Osoegawa, Naohiko Harada, Yoichiro Iboshi, Yorinobu Sumida, Makoto Nakamuta, Eiichi Suematsu, Hiroyuki Kobayashi, Eikichi Ihara

Faculty of Medical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Intestinal mucosal injury that develops as a complication of tocilizumab (TCZ) is usually associated with diverticulosis. We herein report a rare case of TCZ-induced intestinal mucosal injury in the absence of diverticulosis. A 74-year-old woman suffering from rheumatoid arthritis started taking TCZ. Six months later, she complained of hematochezia and abdominal pain. Colonoscopy revealed multiple ulcers spreading from the cecum to the transverse colon but no diverticulosis. These lesions were cured at three months after the discontinuation of TCZ. We should consider TCZ as a risk factor for intestinal mucosal injury, even if patients have no history of intestinal disease associated with diverticulosis.

Original language	English
Pages (from-to)	1011-1014
Number of pages	4
Journal	Internal Medicine
Volume	61
Issue number	7
DOIs	https://doi.org/10.2169/internalmedicine.8031-21
Publication status	Published - 2022

All Science Journal Classification (ASJC) codes

Internal Medicine

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10.2169/internalmedicine.8031-21

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abstract = "Intestinal mucosal injury that develops as a complication of tocilizumab (TCZ) is usually associated with diverticulosis. We herein report a rare case of TCZ-induced intestinal mucosal injury in the absence of diverticulosis. A 74-year-old woman suffering from rheumatoid arthritis started taking TCZ. Six months later, she complained of hematochezia and abdominal pain. Colonoscopy revealed multiple ulcers spreading from the cecum to the transverse colon but no diverticulosis. These lesions were cured at three months after the discontinuation of TCZ. We should consider TCZ as a risk factor for intestinal mucosal injury, even if patients have no history of intestinal disease associated with diverticulosis.",

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AU - Ohkubo, Akito

AU - Osoegawa, Takashi

AU - Harada, Naohiko

AU - Iboshi, Yoichiro

AU - Sumida, Yorinobu

AU - Nakamuta, Makoto

AU - Suematsu, Eiichi

AU - Kobayashi, Hiroyuki

AU - Ihara, Eikichi

PY - 2022

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AB - Intestinal mucosal injury that develops as a complication of tocilizumab (TCZ) is usually associated with diverticulosis. We herein report a rare case of TCZ-induced intestinal mucosal injury in the absence of diverticulosis. A 74-year-old woman suffering from rheumatoid arthritis started taking TCZ. Six months later, she complained of hematochezia and abdominal pain. Colonoscopy revealed multiple ulcers spreading from the cecum to the transverse colon but no diverticulosis. These lesions were cured at three months after the discontinuation of TCZ. We should consider TCZ as a risk factor for intestinal mucosal injury, even if patients have no history of intestinal disease associated with diverticulosis.

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A Rare Case of Rheumatoid Arthritis with Tocilizumab-induced Intestinal Mucosal Injury

Abstract

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