A rat model of esophageal varices

Kazuo Tanoue, Seigo Kitano, Makoto Hashizume, Hiroya Wada, Keizo Sugimachi

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

We have developed a new method for inducing portal hypertension and esophageal varices in rats—partial ligation of the portal vein after devascularization of the circumference of the left renal vein and complete ligation of the portal vein on the fifth day thereafter. Thirty rats were separated into groups of 10, control (sham operation), complete portal ligation only and complete portal ligation plus devascularization. Two weeks after the surgery, the presence of esophageal varices in rats with complete portal ligation plus devas‐cularization was confirmed by portography and by the histological findings. The diameter (mean ± SD) of the submucosal veins of the lower esophagus in the complete portal ligation plus devascularization group (219.4 ± 86.6 μm) was significantly larger than that in the complete portal ligation group (99.8 ± 53.4 μm) or in the control group (30.5 ± 16.6 μm) (p <0.01). Vascular structures of the lower esophagus closely resembled those in humans with esophageal varices. This new technique is simple, rapid and reliable, and application can be made to various experimental studies on portal hypertension. (HEPATOLOGY 1991;353–358).

Original languageEnglish
Pages (from-to)353-358
Number of pages6
JournalHepatology
Volume13
Issue number2
DOIs
Publication statusPublished - Jan 1 1991

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Esophageal and Gastric Varices
Ligation
Portal Hypertension
Portal Vein
Esophagus
Portography
Control Groups
Renal Veins
Blood Vessels
Veins

All Science Journal Classification (ASJC) codes

  • Hepatology

Cite this

Tanoue, K., Kitano, S., Hashizume, M., Wada, H., & Sugimachi, K. (1991). A rat model of esophageal varices. Hepatology, 13(2), 353-358. https://doi.org/10.1002/hep.1840130224

A rat model of esophageal varices. / Tanoue, Kazuo; Kitano, Seigo; Hashizume, Makoto; Wada, Hiroya; Sugimachi, Keizo.

In: Hepatology, Vol. 13, No. 2, 01.01.1991, p. 353-358.

Research output: Contribution to journalArticle

Tanoue, K, Kitano, S, Hashizume, M, Wada, H & Sugimachi, K 1991, 'A rat model of esophageal varices', Hepatology, vol. 13, no. 2, pp. 353-358. https://doi.org/10.1002/hep.1840130224
Tanoue K, Kitano S, Hashizume M, Wada H, Sugimachi K. A rat model of esophageal varices. Hepatology. 1991 Jan 1;13(2):353-358. https://doi.org/10.1002/hep.1840130224
Tanoue, Kazuo ; Kitano, Seigo ; Hashizume, Makoto ; Wada, Hiroya ; Sugimachi, Keizo. / A rat model of esophageal varices. In: Hepatology. 1991 ; Vol. 13, No. 2. pp. 353-358.
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