A receptor for green tea polyphenol EGCG

Hirofumi Tachibana, Kiyoshi Koga, Yoshinori Fujimura, Koji Yamada

Research output: Contribution to journalArticle

514 Citations (Scopus)

Abstract

The major polyphenol in green tea, (-)-epigallocatechin-3-gallate (EGCG), has been shown to prevent carcinogenesis. We have identified a receptor that mediates the anticancer activity of EGCG. Expression of the metastasis-associated 67-kDa laminin receptor confers EGCG responsiveness to cancer cells at physiologically relevant concentrations. Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar Kd value.

Original languageEnglish
Pages (from-to)380-381
Number of pages2
JournalNature Structural and Molecular Biology
Volume11
Issue number4
DOIs
Publication statusPublished - Apr 1 2004

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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