A regulatory role of interleukin 15 in wound healing and mucosal infection in mice

Yoshiko Kagimoto, Hisakata Yamada, Takahiro Ishikawa, Naoyoshi Maeda, Fumi Goshima, Yukihiro Nishiyama, Masutaka Furue, Yasunobu Yoshikai

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Abstract

IL-15 plays a critical role in the development and maturation of γδ intraepithelial T lymphocytes (IEL), which are known to play important roles in wound healing and resolving inflammation in mice. In this study, we found that IL-15 transgenic (Tg) mice, under the control of a MHC Class I promoter, exhibited accelerated wound healing but were highly susceptible to genital infection with HSV-2. The IEL in the skin and reproductive organs of IL-15 Tg mice produced an aberrantly higher level of TGF-β1 upon TCR triggering than in control mice. In vivo neutralization of TGF-β ameliorated the susceptibility of IL-15 Tg mice to genital HSV-2 infection. Taken together, overexpression of IL-15 may stimulate IEL to produce TGF-β1, promoting wound healing but impeding protection against genital HSV-2 infection.

Original languageEnglish
Pages (from-to)165-172
Number of pages8
JournalJournal of Leukocyte Biology
Volume83
Issue number1
DOIs
Publication statusPublished - Jan 1 2008

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All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Cell Biology

Cite this

Kagimoto, Y., Yamada, H., Ishikawa, T., Maeda, N., Goshima, F., Nishiyama, Y., ... Yoshikai, Y. (2008). A regulatory role of interleukin 15 in wound healing and mucosal infection in mice. Journal of Leukocyte Biology, 83(1), 165-172. https://doi.org/10.1189/jlb.0307137