A relationship between the evolution of hepatitis C virus variants, liver damage, and hepatocellular carcinoma in patients with hepatitis C viremia

Jun Hayashi, Norihiro Furusyo, Iwao Ariyama, Yasunori Sawayama, Yoshitaka Etoh, Seizaburo Kashiwagi

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To clarify the mechanism of liver damage induced by hepatitis C Virus (HCV) and to determine whether the damage is related to hepatocellular carcinoma (HCC), HCV RNA levels were measured serially, and HCV genome mutations were analyzed from serum of 274 Japanese patients with chronic HCV viremia during 1993-1998. All patients had alanine aminotransferase (ALT) levels measured during 1986-1998. Patients with consistently normal ALT levels had identical and highly conserved HCV core regions; however, those with consistently abnormal ALT levels had quasi species, and the population of the quasi species changed over time. HCV RNA levels did not change in the 274 patients. HCC developed in 31% of 80 patients with consistently abnormal ALT levels and in 4% of 92 patients with intermittently abnormal ALT levels but never in 102 patients with ALT levels consistently normal during 1993- 1998. In patients with chronic HCV viremia, persistent liver damage plays an important role in the development of HCC.

Original languageEnglish
Pages (from-to)1523-1527
Number of pages5
JournalJournal of Infectious Diseases
Issue number5
Publication statusPublished - Jun 28 2000


All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Infectious Diseases

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