TY - JOUR
T1 - A retrospective analysis of haplo-identical HLA-mismatch hematopoietic transplantation without posttransplantation cyclophosphamide for GVHD prophylaxis in patients with adult T-cell leukemia–lymphoma
AU - on behalf of ATL Working Group of the Japan Society for Hematopoietic Cell Transplantation
AU - Yoshimitsu, Makoto
AU - Utsunomiya, Atae
AU - Fuji, Shigeo
AU - Fujiwara, Hiroshi
AU - Fukuda, Takahiro
AU - Ogawa, Hiroyasu
AU - Takatsuka, Yoshifusa
AU - Ishitsuka, Kenji
AU - Yokota, Akira
AU - Okumura, Hirokazu
AU - Ishii, Kazuyoshi
AU - Nishikawa, Akinori
AU - Eto, Tetsuya
AU - Yonezawa, Akihito
AU - Miyashita, Kaname
AU - Tsukada, Junichi
AU - Tanaka, Junji
AU - Atsuta, Yoshiko
AU - Kato, Koji
N1 - Publisher Copyright:
© 2018, Springer Nature Limited.
PY - 2019/8/1
Y1 - 2019/8/1
N2 - Currently, allogeneic hematopoietic stem cell transplantation (allo-HCT) is the only available curative modality for patients with adult T-cell leukemia–lymphoma (ATL). When used in conjunction with posttransplantation cyclophosphamide (PTCY) for graft-versus-host disease prophylaxis, allo-HCT from an HLA haplo-identical donor yields promising outcomes for many diseases other than ATL. However, appropriate comparisons with other donor sources, especially cord blood and conventional HLA haplo-identical donors, are needed to validate the safety and efficacy of this modality. In this study, we retrospectively evaluated the outcome of allo-HCT without PTCY in patients with ATL registered in the Japan Society for Hematopoietic Cell Transplantation TRUMP database between 1985 and 2015. During that period, 46 patients received allo-HCT without PTCY and survivors were followed for a median of 2316.5 days (range: 220–3884 days). Although the estimated 1- and 5-year overall survival rates of the entire cohort were 34.5% and 17.7%, respectively, the cumulative 1- and 5-year non-ATL mortality rates of 41.3% and 55.8%, respectively, were high. The results of our study will serve as a platform for discussions of the safety and efficacy of haplo-HCT for future clinical trials in patients with ATL.
AB - Currently, allogeneic hematopoietic stem cell transplantation (allo-HCT) is the only available curative modality for patients with adult T-cell leukemia–lymphoma (ATL). When used in conjunction with posttransplantation cyclophosphamide (PTCY) for graft-versus-host disease prophylaxis, allo-HCT from an HLA haplo-identical donor yields promising outcomes for many diseases other than ATL. However, appropriate comparisons with other donor sources, especially cord blood and conventional HLA haplo-identical donors, are needed to validate the safety and efficacy of this modality. In this study, we retrospectively evaluated the outcome of allo-HCT without PTCY in patients with ATL registered in the Japan Society for Hematopoietic Cell Transplantation TRUMP database between 1985 and 2015. During that period, 46 patients received allo-HCT without PTCY and survivors were followed for a median of 2316.5 days (range: 220–3884 days). Although the estimated 1- and 5-year overall survival rates of the entire cohort were 34.5% and 17.7%, respectively, the cumulative 1- and 5-year non-ATL mortality rates of 41.3% and 55.8%, respectively, were high. The results of our study will serve as a platform for discussions of the safety and efficacy of haplo-HCT for future clinical trials in patients with ATL.
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U2 - 10.1038/s41409-018-0400-5
DO - 10.1038/s41409-018-0400-5
M3 - Article
C2 - 30546068
AN - SCOPUS:85058470243
VL - 54
SP - 1266
EP - 1274
JO - Bone Marrow Transplantation
JF - Bone Marrow Transplantation
SN - 0268-3369
IS - 8
ER -