A retrospective multicenter study of carbon ion radiotherapy for locally advanced olfactory neuroblastomas

Hiroaki Suefuji, Masashi Koto, Yusuke Demizu, Jun Ichi Saitoh, Yoshiyuki Shioyama, Hiroshi Tsuji, Tomoaki Okimoto, Tatsuya Ohno, Kenji Nemoto, Takashi Nakano, Tadashi Kamada

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The purpose was to evaluate efficacy and safety of carbon ion radiotherapy (C-ion RT) in patients with locally advanced olfactory neuroblastomas (ONBs). This study was a sub-analysis of the Japan Carbon-Ion Radiation Oncology Study Group Study (1402 HN, UMIN000024473). Clinical data of T4 ONBs treated with C-ion RT at four Institutions between November 2003 and December 2014 were retrospectively reviewed. Twenty-one patients underwent C-ion RT. Seven patients had T4a and 14 had T4b tumours without cervical node metastases. The median follow-up period was 39 (range=5-111) months. The 3-year overall survival and local control rates were 88.4% and 83.0%, respectively. Grade 4 late toxicity was observed in three patients, including ipsilateral optic nerve disorder (n=2) and ipsilateral retinopathy (n=1). C-Ion RT is effective and can be a curative modality for T4 ONBs. Prospective multicenter studies are warranted to confirm these findings.

Original languageEnglish
Pages (from-to)1665-1670
Number of pages6
JournalAnticancer research
Volume38
Issue number3
DOIs
Publication statusPublished - Mar 2018

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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