A retrospective multicenter study of carbon ion radiotherapy for locally advanced olfactory neuroblastomas

Hiroaki Suefuji; Masashi Koto; Yusuke Demizu; Jun Ichi Saitoh; Yoshiyuki Shioyama; Hiroshi Tsuji; Tomoaki Okimoto; Tatsuya Ohno; Kenji Nemoto; Takashi Nakano; Tadashi Kamada

doi:10.21873/anticanres.12399

A retrospective multicenter study of carbon ion radiotherapy for locally advanced olfactory neuroblastomas

Hiroaki Suefuji, Masashi Koto, Yusuke Demizu, Jun Ichi Saitoh, Yoshiyuki Shioyama, Hiroshi Tsuji, Tomoaki Okimoto, Tatsuya Ohno, Kenji Nemoto, Takashi Nakano, Tadashi Kamada

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

The purpose was to evaluate efficacy and safety of carbon ion radiotherapy (C-ion RT) in patients with locally advanced olfactory neuroblastomas (ONBs). This study was a sub-analysis of the Japan Carbon-Ion Radiation Oncology Study Group Study (1402 HN, UMIN000024473). Clinical data of T4 ONBs treated with C-ion RT at four Institutions between November 2003 and December 2014 were retrospectively reviewed. Twenty-one patients underwent C-ion RT. Seven patients had T4a and 14 had T4b tumours without cervical node metastases. The median follow-up period was 39 (range=5-111) months. The 3-year overall survival and local control rates were 88.4% and 83.0%, respectively. Grade 4 late toxicity was observed in three patients, including ipsilateral optic nerve disorder (n=2) and ipsilateral retinopathy (n=1). C-Ion RT is effective and can be a curative modality for T4 ONBs. Prospective multicenter studies are warranted to confirm these findings.

Original language	English
Pages (from-to)	1665-1670
Number of pages	6
Journal	Anticancer research
Volume	38
Issue number	3
DOIs	https://doi.org/10.21873/anticanres.12399
Publication status	Published - Mar 2018
Externally published	Yes

All Science Journal Classification (ASJC) codes

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.21873/anticanres.12399

Cite this

@article{746ca71645094f298751b747b106b964,

title = "A retrospective multicenter study of carbon ion radiotherapy for locally advanced olfactory neuroblastomas",

abstract = "The purpose was to evaluate efficacy and safety of carbon ion radiotherapy (C-ion RT) in patients with locally advanced olfactory neuroblastomas (ONBs). This study was a sub-analysis of the Japan Carbon-Ion Radiation Oncology Study Group Study (1402 HN, UMIN000024473). Clinical data of T4 ONBs treated with C-ion RT at four Institutions between November 2003 and December 2014 were retrospectively reviewed. Twenty-one patients underwent C-ion RT. Seven patients had T4a and 14 had T4b tumours without cervical node metastases. The median follow-up period was 39 (range=5-111) months. The 3-year overall survival and local control rates were 88.4% and 83.0%, respectively. Grade 4 late toxicity was observed in three patients, including ipsilateral optic nerve disorder (n=2) and ipsilateral retinopathy (n=1). C-Ion RT is effective and can be a curative modality for T4 ONBs. Prospective multicenter studies are warranted to confirm these findings.",

author = "Hiroaki Suefuji and Masashi Koto and Yusuke Demizu and Saitoh, {Jun Ichi} and Yoshiyuki Shioyama and Hiroshi Tsuji and Tomoaki Okimoto and Tatsuya Ohno and Kenji Nemoto and Takashi Nakano and Tadashi Kamada",

year = "2018",

month = mar,

doi = "10.21873/anticanres.12399",

language = "English",

volume = "38",

pages = "1665--1670",

journal = "Anticancer Research",

issn = "0250-7005",

publisher = "International Institute of Anticancer Research",

number = "3",

}

TY - JOUR

T1 - A retrospective multicenter study of carbon ion radiotherapy for locally advanced olfactory neuroblastomas

AU - Suefuji, Hiroaki

AU - Koto, Masashi

AU - Demizu, Yusuke

AU - Saitoh, Jun Ichi

AU - Shioyama, Yoshiyuki

AU - Tsuji, Hiroshi

AU - Okimoto, Tomoaki

AU - Ohno, Tatsuya

AU - Nemoto, Kenji

AU - Nakano, Takashi

AU - Kamada, Tadashi

PY - 2018/3

Y1 - 2018/3

N2 - The purpose was to evaluate efficacy and safety of carbon ion radiotherapy (C-ion RT) in patients with locally advanced olfactory neuroblastomas (ONBs). This study was a sub-analysis of the Japan Carbon-Ion Radiation Oncology Study Group Study (1402 HN, UMIN000024473). Clinical data of T4 ONBs treated with C-ion RT at four Institutions between November 2003 and December 2014 were retrospectively reviewed. Twenty-one patients underwent C-ion RT. Seven patients had T4a and 14 had T4b tumours without cervical node metastases. The median follow-up period was 39 (range=5-111) months. The 3-year overall survival and local control rates were 88.4% and 83.0%, respectively. Grade 4 late toxicity was observed in three patients, including ipsilateral optic nerve disorder (n=2) and ipsilateral retinopathy (n=1). C-Ion RT is effective and can be a curative modality for T4 ONBs. Prospective multicenter studies are warranted to confirm these findings.

AB - The purpose was to evaluate efficacy and safety of carbon ion radiotherapy (C-ion RT) in patients with locally advanced olfactory neuroblastomas (ONBs). This study was a sub-analysis of the Japan Carbon-Ion Radiation Oncology Study Group Study (1402 HN, UMIN000024473). Clinical data of T4 ONBs treated with C-ion RT at four Institutions between November 2003 and December 2014 were retrospectively reviewed. Twenty-one patients underwent C-ion RT. Seven patients had T4a and 14 had T4b tumours without cervical node metastases. The median follow-up period was 39 (range=5-111) months. The 3-year overall survival and local control rates were 88.4% and 83.0%, respectively. Grade 4 late toxicity was observed in three patients, including ipsilateral optic nerve disorder (n=2) and ipsilateral retinopathy (n=1). C-Ion RT is effective and can be a curative modality for T4 ONBs. Prospective multicenter studies are warranted to confirm these findings.

UR - http://www.scopus.com/inward/record.url?scp=85043432899&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85043432899&partnerID=8YFLogxK

U2 - 10.21873/anticanres.12399

DO - 10.21873/anticanres.12399

M3 - Article

C2 - 29491100

AN - SCOPUS:85043432899

SN - 0250-7005

VL - 38

SP - 1665

EP - 1670

JO - Anticancer Research

JF - Anticancer Research

IS - 3

ER -

A retrospective multicenter study of carbon ion radiotherapy for locally advanced olfactory neuroblastomas

Abstract

All Science Journal Classification (ASJC) codes

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this