TY - JOUR
T1 - A review on Tsukushi
T2 - mammalian development, disorders, and therapy
AU - Istiaq, Arif
AU - Ohta, Kunimasa
N1 - Funding Information:
This work was supported by JST SPRING: Grant Number JPMJSP2127, Kumamoto University; Advanced Research Project Stem Cell-Based Tissue Regeneration, Research and Education Unit; Program for Leading Graduate Schools “HIGO Program” in Kumamoto University (AI).
Publisher Copyright:
© 2022, The International CCN Society.
PY - 2022
Y1 - 2022
N2 - Tsukushi (TSK), a leucine-rich peptidoglycan in the extracellular compartment, mediates multiple signaling pathways that are critical for development and metabolism. TSK regulates signaling pathways that eventually control cellular communication, proliferation, and cell fate determination. Research on TSK has become more sophisticated in recent years, illustrating its involvement in the physiology and pathophysiology of neural, genetic, and metabolic diseases. In a recent study, we showed that TSK therapy reversed the pathophysiological abnormalities of the hydrocephalic (a neurological disorder) brain in mice. This review summarizes the roles of TSK in key signaling processes in the mammalian development, disorders, and evaluating its possible therapeutic and diagnostic potential.
AB - Tsukushi (TSK), a leucine-rich peptidoglycan in the extracellular compartment, mediates multiple signaling pathways that are critical for development and metabolism. TSK regulates signaling pathways that eventually control cellular communication, proliferation, and cell fate determination. Research on TSK has become more sophisticated in recent years, illustrating its involvement in the physiology and pathophysiology of neural, genetic, and metabolic diseases. In a recent study, we showed that TSK therapy reversed the pathophysiological abnormalities of the hydrocephalic (a neurological disorder) brain in mice. This review summarizes the roles of TSK in key signaling processes in the mammalian development, disorders, and evaluating its possible therapeutic and diagnostic potential.
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U2 - 10.1007/s12079-022-00669-z
DO - 10.1007/s12079-022-00669-z
M3 - Review article
AN - SCOPUS:85125377986
JO - Journal of Cell Communication and Signaling
JF - Journal of Cell Communication and Signaling
SN - 1873-9601
ER -