A role for fission yeast rab GTPase Ypt7p in sporulation

Jun Kashiwazaki, Taro Nakamura, Tomoko Iwaki, Kaoru Takegawa, Chikashi Shimoda

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

Ypt7p, a fission yeast (Schizosaccharomyces pombe) homologue of Rab7 GTPase, mediates fusion of endosomes to vacuoles and homotypic vacuole fusion. Here, we report that Ypt7p plays important roles in sporulation. Most ypt7Δ asci produced less than four spores, which were apparently immature and germinated at low frequency. Furthermore, ypt7Δ cells were defective in development of the forespore membranes. Vacuoles in sporulating cells were found to undergo extensive homotypic vacuole fusion to form a few large compartments occupying the entire cytoplasm of asci. This extensive vacuole fusion depended on Ypt7p.

Original languageEnglish
Pages (from-to)43-49
Number of pages7
JournalCell structure and function
Volume30
Issue number2
DOIs
Publication statusPublished - 2005
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'A role for fission yeast rab GTPase Ypt7p in sporulation'. Together they form a unique fingerprint.

Cite this