A Sapecin Homologue of Holotrichia Diomphalia: Purification, Sequencing and Determination of Disulfide Pairs

So Lee, Hyun Moon, Bok Lee, Shunichiro Kawabata, Shunji Natori, Shoichiro Kurata

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

We purified and characterized a sapecin homologue, named holotricin 1, from the hemolymph of immunized larvae of a coleopteran insect, Holotrichia diomphalia. We determined its complete amino acid sequence and three disulfide pairs. Holotricin 1 consisted of 43 amino acid residues and showed potent antibacterial activity against gram-positive bacteria, but antibacterial activity against gram-negative bacteria was not obvious.

Original languageEnglish
Pages (from-to)457-459
Number of pages3
JournalBiological and Pharmaceutical Bulletin
Volume18
Issue number3
DOIs
Publication statusPublished - 1995

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

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