A shortcut and stereoselective synthesis of 1-β-alkyl-2-deoxy-D-ribose derivatives has been achieved via Wittig-Horner-Emmons reaction followed by intramolecular 1,4-addition. After the systematic investigation of the effects of the base and the solvent, the best β-selectivity, as much as 12:1, was obtained with potassium tert-butoxide in THF.
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Organic Chemistry