A single high-resolution HLA mismatch has a similar adverse impact on the outcome of related hematopoietic stem cell transplantation as a single low-resolution HLA mismatch

on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The relative importance of the resolution level of HLA typing has not been fully defined for related donor transplantation. To address this question, we retrospectively evaluated patients who underwent a first related hematopoietic stem cell transplantation (HSCT) from 2000 to 2011 from an HLA high-resolution matched (MRD, n=2,244), high-resolution 1 locus-mismatched (HR-MMRD, n=116), or low-resolution 1 locus-mismatched related donor (LR-MMRD, n=396) in the graft-versus-host direction at three loci (HLA A, B, and DRB1) using the database of the Japan Society for Hematopoietic Cell Transplantation. The median age was 40 years (0-74). The median follow-up duration of surviving patients was 950 days. Although the cumulative incidences of grade III-IV acute graft-versus-host disease (GVHD) in the HR-MMRD and LR-MMRD groups were significantly higher than those in the MRD group (HR-MMRD 19.8%, LR-MMRD 20.4%, and MRD 9.5%), there was no statistically significant difference between the HR-MMRD and LR-MMRD groups (P=0.65). Although both HR-MMRD and LR-MMRD were significantly associated with an increased risk of non-relapse mortality and a worse overall survival, there was no statistically significant difference between the HR-MMRD and LR-MMRD groups. In conclusion, LR-MM and HR-MM have a similar adverse impact on the outcome in related HSCT.

Original languageEnglish
Pages (from-to)618-623
Number of pages6
JournalAmerican Journal of Hematology
Volume90
Issue number7
DOIs
Publication statusPublished - Jul 1 2015

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Hematopoietic Stem Cell Transplantation
Tissue Donors
HLA-DRB1 Chains
Histocompatibility Testing
HLA-A Antigens
HLA-B Antigens
Cell Transplantation
Graft vs Host Disease
Japan
Transplantation
Databases
Transplants
Survival
Mortality
Incidence
Direction compound

All Science Journal Classification (ASJC) codes

  • Hematology

Cite this

A single high-resolution HLA mismatch has a similar adverse impact on the outcome of related hematopoietic stem cell transplantation as a single low-resolution HLA mismatch. / on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation.

In: American Journal of Hematology, Vol. 90, No. 7, 01.07.2015, p. 618-623.

Research output: Contribution to journalArticle

on behalf of the HLA Working Group of the Japan Society for Hematopoietic Cell Transplantation. / A single high-resolution HLA mismatch has a similar adverse impact on the outcome of related hematopoietic stem cell transplantation as a single low-resolution HLA mismatch. In: American Journal of Hematology. 2015 ; Vol. 90, No. 7. pp. 618-623.
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abstract = "The relative importance of the resolution level of HLA typing has not been fully defined for related donor transplantation. To address this question, we retrospectively evaluated patients who underwent a first related hematopoietic stem cell transplantation (HSCT) from 2000 to 2011 from an HLA high-resolution matched (MRD, n=2,244), high-resolution 1 locus-mismatched (HR-MMRD, n=116), or low-resolution 1 locus-mismatched related donor (LR-MMRD, n=396) in the graft-versus-host direction at three loci (HLA A, B, and DRB1) using the database of the Japan Society for Hematopoietic Cell Transplantation. The median age was 40 years (0-74). The median follow-up duration of surviving patients was 950 days. Although the cumulative incidences of grade III-IV acute graft-versus-host disease (GVHD) in the HR-MMRD and LR-MMRD groups were significantly higher than those in the MRD group (HR-MMRD 19.8{\%}, LR-MMRD 20.4{\%}, and MRD 9.5{\%}), there was no statistically significant difference between the HR-MMRD and LR-MMRD groups (P=0.65). Although both HR-MMRD and LR-MMRD were significantly associated with an increased risk of non-relapse mortality and a worse overall survival, there was no statistically significant difference between the HR-MMRD and LR-MMRD groups. In conclusion, LR-MM and HR-MM have a similar adverse impact on the outcome in related HSCT.",
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AU - Fuji, Shigeo

AU - Kanda, Junya

AU - Kato, Shunichi

AU - Ikegame, Kazuhiro

AU - Morishima, Satoko

AU - Miyamoto, Toshihiro

AU - Hidaka, Michihiro

AU - Kubo, Kohmei

AU - Miyamura, Koichi

AU - Tsudo, Mitsuru

AU - Kobayashi, Hikaru

AU - Maesako, Yoshitomo

AU - Eto, Tetsuya

AU - Adachi, Souichi

AU - Ichinohe, Tatsuo

AU - Atsuta, Yoshiko

AU - Kanda, Yoshinobu

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