A solid-phase synthesis for β-turn mimetics of sialyl Lewis X

Kiriko Kurokawa, Hiroshi Kumihara, Hirosato Kondo

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

A solid-phase synthesis of heterocyclic β-turn mimetics of sialyl Lewis X, which is a natural carbohydrate ligand of selectins, was established. This synthetic method could be very useful for drug discovery of selectin antagonists using combinatorial chemistry techniques. (C) 2000 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)1827-1830
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number16
DOIs
Publication statusPublished - Aug 21 2000
Externally publishedYes

Fingerprint

Selectins
Solid-Phase Synthesis Techniques
Combinatorial Chemistry Techniques
Drug Discovery
Carbohydrates
Ligands

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

A solid-phase synthesis for β-turn mimetics of sialyl Lewis X. / Kurokawa, Kiriko; Kumihara, Hiroshi; Kondo, Hirosato.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 10, No. 16, 21.08.2000, p. 1827-1830.

Research output: Contribution to journalArticle

Kurokawa, Kiriko ; Kumihara, Hiroshi ; Kondo, Hirosato. / A solid-phase synthesis for β-turn mimetics of sialyl Lewis X. In: Bioorganic and Medicinal Chemistry Letters. 2000 ; Vol. 10, No. 16. pp. 1827-1830.
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