A soybean peptide isolate diet promotes postprandial carbohydrate oxidation and energy expenditure in type II diabetic mice

Kengo Ishihara, Shinichi Oyaizu, Yoshiko Fukuchi, Wataru Mizunoya, Kikumi Segawa, Miki Takahashi, Yukiko Mita, Yoko Fukuya, Tohru Fushiki, Kyoden Yasumoto

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The aim of the present study was to determine the effects of dietary proteins on the oxidation of dietary carbohydrate and lipids in type II diabetic mice. KK-Ay strain mice were provided free access to a high fat diet (30% of energy as fat) for an initial 4-wk period to induce diabetes. To reduce body weight gain, the mice were subsequently fed restrictive isoenergetic and isonitrogenous diets (35% of energy as protein and 5% as fat) based on either casein or soy protein isolate hydrolysate (SPI-H) for 4 wk. To measure exogenous carbohydrate and lipid oxidation, the mice were fed a diet containing 13C-glucose or 13C-triolein while they were in a respiratory chamber for 72 h. Postprandial energy expenditure was higher in the SPI-H than in the casein group; this difference was due to an increase in postprandial exogenous and endogenous carbohydrate oxidation. There were no differences in 24-h energy expenditure between dietary groups. Oxidation of exogenous carbohydrate tended to be higher (P = 0.054) in the SPI-H group during the 24 h of measurement. Fecal excretion of 13C-glucose was lower but the excretion of lipid was higher in mice fed the SPI-H diet than in casein-fed mice. These results indicate that in type II diabetic mice, dietary SPI-H not only inhibits the absorption of dietary lipids and increases the absorption of dietary carbohydrates but also augments postprandial energy expenditure, which is accompanied by a postprandial increase in oxidation of dietary carbohydrates.

Original languageEnglish
Pages (from-to)752-757
Number of pages6
JournalJournal of Nutrition
Volume133
Issue number3
DOIs
Publication statusPublished - Mar 1 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Fingerprint Dive into the research topics of 'A soybean peptide isolate diet promotes postprandial carbohydrate oxidation and energy expenditure in type II diabetic mice'. Together they form a unique fingerprint.

  • Cite this

    Ishihara, K., Oyaizu, S., Fukuchi, Y., Mizunoya, W., Segawa, K., Takahashi, M., Mita, Y., Fukuya, Y., Fushiki, T., & Yasumoto, K. (2003). A soybean peptide isolate diet promotes postprandial carbohydrate oxidation and energy expenditure in type II diabetic mice. Journal of Nutrition, 133(3), 752-757. https://doi.org/10.1093/jn/133.3.752