A spatiotemporal signature of cortical pain relief by tactile stimulation: An MEG study

Mariko Hayamizu, Koichi Hagiwara, Naruhito Hironaga, Katsuya Ogata, Sumio Hoka, Shozo Tobimatsu

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Abstract

Recently, the cortical mechanisms of tactile-induced analgesia have been investigated; however, spatiotemporal characteristics have not been fully elucidated. The insular–opercular region integrates multiple sensory inputs, and nociceptive modulation by other sensory inputs occurs in this area. In this study, we focused on the insular–opercular region to characterize the spatiotemporal signature of tactile-induced analgesia using magnetoencephalography in 11 healthy subjects. Aδ (intra-epidermal electrical stimulation) inputs were modified by Aβ (mechanical tactile stimulation) selective stimulation, either independently or concurrently, to the right forearm. The optimal inter-stimulus interval (ISI) for cortical level modulation was determined after comparing the 40-, 60-, and 80-ms ISI conditions, and the calculated cortical arrival time difference between Aδ and Aβ inputs. Subsequently, we adopted a 60-ms ISI for cortical modulation and a 0-ms ISI for spinal level modulation. Source localization using minimum norm estimates demonstrated that pain-related activity was located in the posterior insula, whereas tactile-related activity was estimated in the parietal operculum. We also found significant inhibition of pain-related activity in the posterior insula due to cortical modulation. In contrast, spinal modulation was observed both in the posterior insula and parietal operculum. Subjective pain, as evaluated by the visual analog scale, also showed significant reduction in both conditions. Therefore, our results demonstrated that the multisensory integration within the posterior insula plays a key role in tactile-induced analgesia.

Original languageEnglish
Pages (from-to)175-183
Number of pages9
JournalNeuroImage
Volume130
DOIs
Publication statusPublished - Apr 15 2016

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All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

Hayamizu, M., Hagiwara, K., Hironaga, N., Ogata, K., Hoka, S., & Tobimatsu, S. (2016). A spatiotemporal signature of cortical pain relief by tactile stimulation: An MEG study. NeuroImage, 130, 175-183. https://doi.org/10.1016/j.neuroimage.2016.01.065