A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure

Masatoshi Maeki, Tatsuyoshi Saito, Yusuke Sato, Takao Yasui, Noritada Kaji, Akihiko Ishida, Hirofumi Tani, Yoshinobu Baba, Hideyoshi Harashima, Manabu Tokeshi

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Formation behavior of lipid nanoparticles (LNPs) in microfluidic devices with a staggered herringbone micromixer (SHM) structure was investigated. The fundamental role for SHMs in LNP formation was demonstrated by determining such factors as the limiting SHM cycle numbers and the effect of flow rate. The SHM cycle numbers and the position of the first SHM were as significant as factors as the flow rate condition for producing the small-size LNPs.

Original languageEnglish
Pages (from-to)46181-46185
Number of pages5
JournalRSC Advances
Volume5
Issue number57
DOIs
Publication statusPublished - Jan 1 2015
Externally publishedYes

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Microfluidics
Lipids
Nanoparticles
Flow rate

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)

Cite this

Maeki, M., Saito, T., Sato, Y., Yasui, T., Kaji, N., Ishida, A., ... Tokeshi, M. (2015). A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure. RSC Advances, 5(57), 46181-46185. https://doi.org/10.1039/c5ra04690d

A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure. / Maeki, Masatoshi; Saito, Tatsuyoshi; Sato, Yusuke; Yasui, Takao; Kaji, Noritada; Ishida, Akihiko; Tani, Hirofumi; Baba, Yoshinobu; Harashima, Hideyoshi; Tokeshi, Manabu.

In: RSC Advances, Vol. 5, No. 57, 01.01.2015, p. 46181-46185.

Research output: Contribution to journalArticle

Maeki, M, Saito, T, Sato, Y, Yasui, T, Kaji, N, Ishida, A, Tani, H, Baba, Y, Harashima, H & Tokeshi, M 2015, 'A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure', RSC Advances, vol. 5, no. 57, pp. 46181-46185. https://doi.org/10.1039/c5ra04690d
Maeki, Masatoshi ; Saito, Tatsuyoshi ; Sato, Yusuke ; Yasui, Takao ; Kaji, Noritada ; Ishida, Akihiko ; Tani, Hirofumi ; Baba, Yoshinobu ; Harashima, Hideyoshi ; Tokeshi, Manabu. / A strategy for synthesis of lipid nanoparticles using microfluidic devices with a mixer structure. In: RSC Advances. 2015 ; Vol. 5, No. 57. pp. 46181-46185.
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