A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves

Julia Kolter, Reinhild Feuerstein, Patrice Zeis, Nora Hagemeyer, Neil Paterson, Paolo d'Errico, Sebastian Baasch, Lukas Amann, Takahiro Masuda, Anne Lösslein, Kourosh Gharun, Melanie Meyer-Luehmann, Claudia Waskow, Claus Werner Franzke, Dominic Grün, Tim Lämmermann, Marco Prinz, Philipp Henneke

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The skin comprises tissue macrophages as the most abundant resident immune cell type. Their diverse tasks including resistance against invading pathogens, attraction of bypassing immune cells from vessels, and tissue repair require dynamic specification. Here, we delineated the postnatal development of dermal macrophages and their differentiation into subsets by adapting single-cell transcriptomics, fate mapping, and imaging. Thereby we identified a phenotypically and transcriptionally distinct subset of prenatally seeded dermal macrophages that self-maintained with very low postnatal exchange by hematopoietic stem cells. These macrophages specifically interacted with sensory nerves and surveilled and trimmed the myelin sheath. Overall, resident dermal macrophages contributed to axon sprouting after mechanical injury. In summary, our data show long-lasting functional specification of macrophages in the dermis that is driven by stepwise adaptation to guiding structures and ensures codevelopment of ontogenetically distinct cells within the same compartment. Macrophages perform a wide variety of functions in mammalian tissues. Kolter and colleagues provide a map of dermal macrophages in mouse skin and identify a subset of embryonic macrophages that populates sensory nerve fibers. These self-maintaining macrophages actively patrol axons and promote nerve regeneration upon tissue damage.

Original languageEnglish
Pages (from-to)1482-1497.e7
JournalImmunity
Volume50
Issue number6
DOIs
Publication statusPublished - Jun 18 2019
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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    Kolter, J., Feuerstein, R., Zeis, P., Hagemeyer, N., Paterson, N., d'Errico, P., Baasch, S., Amann, L., Masuda, T., Lösslein, A., Gharun, K., Meyer-Luehmann, M., Waskow, C., Franzke, C. W., Grün, D., Lämmermann, T., Prinz, M., & Henneke, P. (2019). A Subset of Skin Macrophages Contributes to the Surveillance and Regeneration of Local Nerves. Immunity, 50(6), 1482-1497.e7. https://doi.org/10.1016/j.immuni.2019.05.009