A suppressor T cell in the human mixed lymphocyte reaction*

A. J. McMichael, T. Sasazuki

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Lymphocytes from an HLA-B7 DW2 homozygous multiparous woman, J.H., failed to respond in the mixed lymphocyte reaction to lymphocytes from her DW1 homozygous husband, W.H., and certain other homozygous typing cells. J.H. lymphocytes could suppress the response of HLA matched responders to W.H. This effect was shown to be radiosensitive and due to a T cell. The suppressor cell showed antigen specificity.

Original languageEnglish
Pages (from-to)368-380
Number of pages13
JournalJournal of Experimental Medicine
Volume146
Issue number2
DOIs
Publication statusPublished - Aug 1 1977

Fingerprint

Mixed Lymphocyte Culture Test
Lymphocytes
T-Lymphocytes
HLA-B7 Antigen
Spouses
Antigens

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

A suppressor T cell in the human mixed lymphocyte reaction*. / McMichael, A. J.; Sasazuki, T.

In: Journal of Experimental Medicine, Vol. 146, No. 2, 01.08.1977, p. 368-380.

Research output: Contribution to journalArticle

McMichael, A. J. ; Sasazuki, T. / A suppressor T cell in the human mixed lymphocyte reaction*. In: Journal of Experimental Medicine. 1977 ; Vol. 146, No. 2. pp. 368-380.
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