A syngeneic hepatocellular carcinoma model rapidly and simply prepared using a hydrodynamics-based procedure

Jeong Hun Kang, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

A rapid and simple method to deliver tumor cells into the liver by intravenous injection of a large volume of tumor cell solution at a high velocity has been developed for use in the preparation of hepatic cancer mouse models. With this hydrodynamics-based procedure, there was a 100% tumor occurrence in the liver and lungs of mice at 2 and 3 weeks, respectively. In contrast, mice injected using a non-hydrodynamics-based system showed no tumor occurrence in the liver 3 weeks after injection, although tumors were present in the lungs. The technique may be useful in the rapid development of hepatic cancer mouse models and in reducing animal mortality during model preparation.

Original languageEnglish
Pages (from-to)336-339
Number of pages4
JournalVeterinary Journal
Volume181
Issue number3
DOIs
Publication statusPublished - Sep 2009

All Science Journal Classification (ASJC) codes

  • Animal Science and Zoology
  • veterinary(all)

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