A syngeneic hepatocellular carcinoma model rapidly and simply prepared using a hydrodynamics-based procedure

Jeong Hun Kang; Takeshi Mori; Takuro Niidome; Yoshiki Katayama

doi:10.1016/j.tvjl.2008.04.001

A syngeneic hepatocellular carcinoma model rapidly and simply prepared using a hydrodynamics-based procedure

Jeong Hun Kang, Takeshi Mori, Takuro Niidome, Yoshiki Katayama

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

A rapid and simple method to deliver tumor cells into the liver by intravenous injection of a large volume of tumor cell solution at a high velocity has been developed for use in the preparation of hepatic cancer mouse models. With this hydrodynamics-based procedure, there was a 100% tumor occurrence in the liver and lungs of mice at 2 and 3 weeks, respectively. In contrast, mice injected using a non-hydrodynamics-based system showed no tumor occurrence in the liver 3 weeks after injection, although tumors were present in the lungs. The technique may be useful in the rapid development of hepatic cancer mouse models and in reducing animal mortality during model preparation.

Original language	English
Pages (from-to)	336-339
Number of pages	4
Journal	Veterinary Journal
Volume	181
Issue number	3
DOIs	https://doi.org/10.1016/j.tvjl.2008.04.001
Publication status	Published - Sept 2009

All Science Journal Classification (ASJC) codes

Animal Science and Zoology
veterinary(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tvjl.2008.04.001

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title = "A syngeneic hepatocellular carcinoma model rapidly and simply prepared using a hydrodynamics-based procedure",

abstract = "A rapid and simple method to deliver tumor cells into the liver by intravenous injection of a large volume of tumor cell solution at a high velocity has been developed for use in the preparation of hepatic cancer mouse models. With this hydrodynamics-based procedure, there was a 100% tumor occurrence in the liver and lungs of mice at 2 and 3 weeks, respectively. In contrast, mice injected using a non-hydrodynamics-based system showed no tumor occurrence in the liver 3 weeks after injection, although tumors were present in the lungs. The technique may be useful in the rapid development of hepatic cancer mouse models and in reducing animal mortality during model preparation.",

author = "Kang, {Jeong Hun} and Takeshi Mori and Takuro Niidome and Yoshiki Katayama",

note = "Funding Information: This work was supported by CREST, Japan Science and Technology Corporation, a grant-in-aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture in Japan, and a Grant-in-aid for Scientific Research from the Ministry of Health, Labour and Welfare.",

year = "2009",

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doi = "10.1016/j.tvjl.2008.04.001",

language = "English",

volume = "181",

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T1 - A syngeneic hepatocellular carcinoma model rapidly and simply prepared using a hydrodynamics-based procedure

AU - Kang, Jeong Hun

AU - Mori, Takeshi

AU - Niidome, Takuro

AU - Katayama, Yoshiki

N1 - Funding Information: This work was supported by CREST, Japan Science and Technology Corporation, a grant-in-aid for Scientific Research from the Ministry of Education, Science, Sports, and Culture in Japan, and a Grant-in-aid for Scientific Research from the Ministry of Health, Labour and Welfare.

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N2 - A rapid and simple method to deliver tumor cells into the liver by intravenous injection of a large volume of tumor cell solution at a high velocity has been developed for use in the preparation of hepatic cancer mouse models. With this hydrodynamics-based procedure, there was a 100% tumor occurrence in the liver and lungs of mice at 2 and 3 weeks, respectively. In contrast, mice injected using a non-hydrodynamics-based system showed no tumor occurrence in the liver 3 weeks after injection, although tumors were present in the lungs. The technique may be useful in the rapid development of hepatic cancer mouse models and in reducing animal mortality during model preparation.

AB - A rapid and simple method to deliver tumor cells into the liver by intravenous injection of a large volume of tumor cell solution at a high velocity has been developed for use in the preparation of hepatic cancer mouse models. With this hydrodynamics-based procedure, there was a 100% tumor occurrence in the liver and lungs of mice at 2 and 3 weeks, respectively. In contrast, mice injected using a non-hydrodynamics-based system showed no tumor occurrence in the liver 3 weeks after injection, although tumors were present in the lungs. The technique may be useful in the rapid development of hepatic cancer mouse models and in reducing animal mortality during model preparation.

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A syngeneic hepatocellular carcinoma model rapidly and simply prepared using a hydrodynamics-based procedure

Abstract

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