A new method for ynolate synthesis via the cleavage of ester dianions has been developed. The key intermediates, ester dianions, generated from α-bromocarboxylic acid ester enolates via lithium-halogen exchange turned out to be so labile that they were cleaved rapidly to give ynolates.
All Science Journal Classification (ASJC) codes
- Drug Discovery
- Organic Chemistry