A synthesis of ynolates via the cleavage of ester dianions

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Abstract

A new method for ynolate synthesis via the cleavage of ester dianions has been developed. The key intermediates, ester dianions, generated from α-bromocarboxylic acid ester enolates via lithium-halogen exchange turned out to be so labile that they were cleaved rapidly to give ynolates.

Original languageEnglish
Pages (from-to)4433-4436
Number of pages4
JournalTetrahedron Letters
Volume38
Issue number25
DOIs
Publication statusPublished - Jun 23 1997
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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