A ten year serological survey of hepatitis A, B and C viruses infections in Nepal.

Y. Sawayama, J. Hayashi, I. Ariyama, Norihiro Furusyo, T. Kawasaki, M. Kawasaki, K. Itoh, G. P. Acharya, S. Kashiwagi

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Abstract

BACKGROUND: In 1987, we reported that the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in Nepal was low, as compared to hepatitis A virus (HAV) infection, and that no human T-lymphotropic type-1 (HTLV-1) infection was found in Nepal. OBJECTIVES: To determine changes in the prevalence of HAV, HBV, and HCV infections between 1987 and 1996 in inhabitants of Bhadrakali (suburban) and Kotyang (rural) villages in Nepal. STUDY DESIGN: We did a cross-sectional survey of 458 inhabitants of two Nepalese villages, to assess the prevalence of antibody to HAV (anti-HAV), antibody to hepatitis B core antigen (anti-HBc), hepatitis B surface antigen (HBsAg), antibody to HCV (anti-HCV), and antibody to HTLV-I (anti-HTLV-I). RESULTS: Anti-HAV was detected in 454 (99.1%), HBsAg in 5 (1.1%), anti-HBc in 33 (7.2%) and anti-HCV in 8 (1.7%) of serum samples tested in 1996. Statistically significant differences by gender or age group were nil. The prevalence of HCV infection was significantly higher in 1996 than in 1987 after adjusting for age of subjects living in the two villages (p < 0.01). The prevalence of HBsAg was significantly higher in 1996 than 1987 in Bhadrakali after adjusting for the factor of age (p < 0.05). Between 1987 and 1996, evidence for HTLV-1 positive residents was nil. CONCLUSION: These results suggest that HAV has been endemic in Nepal for long time while not of HBV, and that HCV infection tends to be increased recently.

Original languageEnglish
Pages (from-to)350-354
Number of pages5
JournalJournal of epidemiology / Japan Epidemiological Association
Volume9
Issue number5
DOIs
Publication statusPublished - Jan 1 1999

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Hepatitis A virus
Nepal
Virus Diseases
Hepatitis B virus
Hepacivirus
Human T-lymphotropic virus 1
Hepatitis B Surface Antigens
Hepatitis B Core Antigens
Hepatitis C Antibodies
Antibodies
Deltaretrovirus Infections
Hepatitis A Antibodies
Age Factors
Age Groups
Cross-Sectional Studies
Surveys and Questionnaires
Serum

All Science Journal Classification (ASJC) codes

  • Epidemiology

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Sawayama, Y., Hayashi, J., Ariyama, I., Furusyo, N., Kawasaki, T., Kawasaki, M., ... Kashiwagi, S. (1999). A ten year serological survey of hepatitis A, B and C viruses infections in Nepal. Journal of epidemiology / Japan Epidemiological Association, 9(5), 350-354. https://doi.org/10.2188/jea.9.350

A ten year serological survey of hepatitis A, B and C viruses infections in Nepal. / Sawayama, Y.; Hayashi, J.; Ariyama, I.; Furusyo, Norihiro; Kawasaki, T.; Kawasaki, M.; Itoh, K.; Acharya, G. P.; Kashiwagi, S.

In: Journal of epidemiology / Japan Epidemiological Association, Vol. 9, No. 5, 01.01.1999, p. 350-354.

Research output: Contribution to journalArticle

Sawayama, Y, Hayashi, J, Ariyama, I, Furusyo, N, Kawasaki, T, Kawasaki, M, Itoh, K, Acharya, GP & Kashiwagi, S 1999, 'A ten year serological survey of hepatitis A, B and C viruses infections in Nepal.', Journal of epidemiology / Japan Epidemiological Association, vol. 9, no. 5, pp. 350-354. https://doi.org/10.2188/jea.9.350
Sawayama, Y. ; Hayashi, J. ; Ariyama, I. ; Furusyo, Norihiro ; Kawasaki, T. ; Kawasaki, M. ; Itoh, K. ; Acharya, G. P. ; Kashiwagi, S. / A ten year serological survey of hepatitis A, B and C viruses infections in Nepal. In: Journal of epidemiology / Japan Epidemiological Association. 1999 ; Vol. 9, No. 5. pp. 350-354.
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abstract = "BACKGROUND: In 1987, we reported that the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in Nepal was low, as compared to hepatitis A virus (HAV) infection, and that no human T-lymphotropic type-1 (HTLV-1) infection was found in Nepal. OBJECTIVES: To determine changes in the prevalence of HAV, HBV, and HCV infections between 1987 and 1996 in inhabitants of Bhadrakali (suburban) and Kotyang (rural) villages in Nepal. STUDY DESIGN: We did a cross-sectional survey of 458 inhabitants of two Nepalese villages, to assess the prevalence of antibody to HAV (anti-HAV), antibody to hepatitis B core antigen (anti-HBc), hepatitis B surface antigen (HBsAg), antibody to HCV (anti-HCV), and antibody to HTLV-I (anti-HTLV-I). RESULTS: Anti-HAV was detected in 454 (99.1{\%}), HBsAg in 5 (1.1{\%}), anti-HBc in 33 (7.2{\%}) and anti-HCV in 8 (1.7{\%}) of serum samples tested in 1996. Statistically significant differences by gender or age group were nil. The prevalence of HCV infection was significantly higher in 1996 than in 1987 after adjusting for age of subjects living in the two villages (p < 0.01). The prevalence of HBsAg was significantly higher in 1996 than 1987 in Bhadrakali after adjusting for the factor of age (p < 0.05). Between 1987 and 1996, evidence for HTLV-1 positive residents was nil. CONCLUSION: These results suggest that HAV has been endemic in Nepal for long time while not of HBV, and that HCV infection tends to be increased recently.",
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T1 - A ten year serological survey of hepatitis A, B and C viruses infections in Nepal.

AU - Sawayama, Y.

AU - Hayashi, J.

AU - Ariyama, I.

AU - Furusyo, Norihiro

AU - Kawasaki, T.

AU - Kawasaki, M.

AU - Itoh, K.

AU - Acharya, G. P.

AU - Kashiwagi, S.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - BACKGROUND: In 1987, we reported that the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in Nepal was low, as compared to hepatitis A virus (HAV) infection, and that no human T-lymphotropic type-1 (HTLV-1) infection was found in Nepal. OBJECTIVES: To determine changes in the prevalence of HAV, HBV, and HCV infections between 1987 and 1996 in inhabitants of Bhadrakali (suburban) and Kotyang (rural) villages in Nepal. STUDY DESIGN: We did a cross-sectional survey of 458 inhabitants of two Nepalese villages, to assess the prevalence of antibody to HAV (anti-HAV), antibody to hepatitis B core antigen (anti-HBc), hepatitis B surface antigen (HBsAg), antibody to HCV (anti-HCV), and antibody to HTLV-I (anti-HTLV-I). RESULTS: Anti-HAV was detected in 454 (99.1%), HBsAg in 5 (1.1%), anti-HBc in 33 (7.2%) and anti-HCV in 8 (1.7%) of serum samples tested in 1996. Statistically significant differences by gender or age group were nil. The prevalence of HCV infection was significantly higher in 1996 than in 1987 after adjusting for age of subjects living in the two villages (p < 0.01). The prevalence of HBsAg was significantly higher in 1996 than 1987 in Bhadrakali after adjusting for the factor of age (p < 0.05). Between 1987 and 1996, evidence for HTLV-1 positive residents was nil. CONCLUSION: These results suggest that HAV has been endemic in Nepal for long time while not of HBV, and that HCV infection tends to be increased recently.

AB - BACKGROUND: In 1987, we reported that the prevalence of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection in Nepal was low, as compared to hepatitis A virus (HAV) infection, and that no human T-lymphotropic type-1 (HTLV-1) infection was found in Nepal. OBJECTIVES: To determine changes in the prevalence of HAV, HBV, and HCV infections between 1987 and 1996 in inhabitants of Bhadrakali (suburban) and Kotyang (rural) villages in Nepal. STUDY DESIGN: We did a cross-sectional survey of 458 inhabitants of two Nepalese villages, to assess the prevalence of antibody to HAV (anti-HAV), antibody to hepatitis B core antigen (anti-HBc), hepatitis B surface antigen (HBsAg), antibody to HCV (anti-HCV), and antibody to HTLV-I (anti-HTLV-I). RESULTS: Anti-HAV was detected in 454 (99.1%), HBsAg in 5 (1.1%), anti-HBc in 33 (7.2%) and anti-HCV in 8 (1.7%) of serum samples tested in 1996. Statistically significant differences by gender or age group were nil. The prevalence of HCV infection was significantly higher in 1996 than in 1987 after adjusting for age of subjects living in the two villages (p < 0.01). The prevalence of HBsAg was significantly higher in 1996 than 1987 in Bhadrakali after adjusting for the factor of age (p < 0.05). Between 1987 and 1996, evidence for HTLV-1 positive residents was nil. CONCLUSION: These results suggest that HAV has been endemic in Nepal for long time while not of HBV, and that HCV infection tends to be increased recently.

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