Abstract
We have previously reported that a nonapeptide thymic hormone, facteur thymique serique (FTS), is involved in the differentiation and activation of intestinal intraepithelial lymphocytes (i-IEL) in mice. In this study, we examined the effect of FTS treatment on enteropathy in a murine model for acute graft-vs.-host disease (GVHD) induced by injection of parental C57BL/6 splenocytes into unirradiated (C57BL/6 X DBA/2) F, hybrids. IFS treatment significantly protected mice from developing acute GVHD as assessed by mortality rate, splenomegaly and enteropathy. The infiltration of donor- derived TCRαβ i-IEL bearing CD8αβ was significantly inhibited in the small intestine of FTS-treated mice, and the frequencies of apoptosis of crypt cells in the intestinal mucosa were decreased in these mice during acute GVHD. These results suggest that IFS treatment contributes to protection against enteropathy of acute GVHD. Thus, FTS may provide a useful approach to control acute GVHD after blood transfusion or bone marrow transplantation.
| Original language | English |
|---|---|
| Pages (from-to) | 883-889 |
| Number of pages | 7 |
| Journal | MICROBIOLOGY and IMMUNOLOGY |
| Volume | 41 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Jan 1 1997 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Microbiology
- Immunology
- Virology
Cite this
A thymic hormone protects mice from enteropathy during acute graft- versus-host disease. / Inagaki-Ohara, Kyoko; Sakai, Tetsu; Koya, Goyo; Awaya, Akira; Yoshikai, Yasunobu.
In: MICROBIOLOGY and IMMUNOLOGY, Vol. 41, No. 11, 01.01.1997, p. 883-889.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A thymic hormone protects mice from enteropathy during acute graft- versus-host disease
AU - Inagaki-Ohara, Kyoko
AU - Sakai, Tetsu
AU - Koya, Goyo
AU - Awaya, Akira
AU - Yoshikai, Yasunobu
PY - 1997/1/1
Y1 - 1997/1/1
N2 - We have previously reported that a nonapeptide thymic hormone, facteur thymique serique (FTS), is involved in the differentiation and activation of intestinal intraepithelial lymphocytes (i-IEL) in mice. In this study, we examined the effect of FTS treatment on enteropathy in a murine model for acute graft-vs.-host disease (GVHD) induced by injection of parental C57BL/6 splenocytes into unirradiated (C57BL/6 X DBA/2) F, hybrids. IFS treatment significantly protected mice from developing acute GVHD as assessed by mortality rate, splenomegaly and enteropathy. The infiltration of donor- derived TCRαβ i-IEL bearing CD8αβ was significantly inhibited in the small intestine of FTS-treated mice, and the frequencies of apoptosis of crypt cells in the intestinal mucosa were decreased in these mice during acute GVHD. These results suggest that IFS treatment contributes to protection against enteropathy of acute GVHD. Thus, FTS may provide a useful approach to control acute GVHD after blood transfusion or bone marrow transplantation.
AB - We have previously reported that a nonapeptide thymic hormone, facteur thymique serique (FTS), is involved in the differentiation and activation of intestinal intraepithelial lymphocytes (i-IEL) in mice. In this study, we examined the effect of FTS treatment on enteropathy in a murine model for acute graft-vs.-host disease (GVHD) induced by injection of parental C57BL/6 splenocytes into unirradiated (C57BL/6 X DBA/2) F, hybrids. IFS treatment significantly protected mice from developing acute GVHD as assessed by mortality rate, splenomegaly and enteropathy. The infiltration of donor- derived TCRαβ i-IEL bearing CD8αβ was significantly inhibited in the small intestine of FTS-treated mice, and the frequencies of apoptosis of crypt cells in the intestinal mucosa were decreased in these mice during acute GVHD. These results suggest that IFS treatment contributes to protection against enteropathy of acute GVHD. Thus, FTS may provide a useful approach to control acute GVHD after blood transfusion or bone marrow transplantation.
UR - http://www.scopus.com/inward/record.url?scp=0031456546&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031456546&partnerID=8YFLogxK
U2 - 10.1111/j.1348-0421.1997.tb01945.x
DO - 10.1111/j.1348-0421.1997.tb01945.x
M3 - Article
VL - 41
SP - 883
EP - 889
JO - Microbiology and Immunology
JF - Microbiology and Immunology
SN - 0385-5600
IS - 11
ER -