A thymic hormone protects mice from enteropathy during acute graft- versus-host disease

Kyoko Inagaki-Ohara, Tetsu Sakai, Goyo Koya, Akira Awaya, Yasunobu Yoshikai

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    Abstract

    We have previously reported that a nonapeptide thymic hormone, facteur thymique serique (FTS), is involved in the differentiation and activation of intestinal intraepithelial lymphocytes (i-IEL) in mice. In this study, we examined the effect of FTS treatment on enteropathy in a murine model for acute graft-vs.-host disease (GVHD) induced by injection of parental C57BL/6 splenocytes into unirradiated (C57BL/6 X DBA/2) F, hybrids. IFS treatment significantly protected mice from developing acute GVHD as assessed by mortality rate, splenomegaly and enteropathy. The infiltration of donor- derived TCRαβ i-IEL bearing CD8αβ was significantly inhibited in the small intestine of FTS-treated mice, and the frequencies of apoptosis of crypt cells in the intestinal mucosa were decreased in these mice during acute GVHD. These results suggest that IFS treatment contributes to protection against enteropathy of acute GVHD. Thus, FTS may provide a useful approach to control acute GVHD after blood transfusion or bone marrow transplantation.

    Original languageEnglish
    Pages (from-to)883-889
    Number of pages7
    JournalMICROBIOLOGY and IMMUNOLOGY
    Volume41
    Issue number11
    DOIs
    Publication statusPublished - Jan 1 1997

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    All Science Journal Classification (ASJC) codes

    • Microbiology
    • Immunology
    • Virology

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