@article{03afbee070e34bf2b9b62d14d7085659,
title = "A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells",
abstract = "Bioinformatics and computational modelling are expected to offer innovative approaches in human medical science. In the present study, we performed computational analyses and made predictions using transcriptome and metabolome datasets obtained from fluorescence-based visualisations of chemotherapy-resistant cancer stem cells (CSCs) in the human oesophagus. This approach revealed an uncharacterized role for the ornithine metabolic pathway in the survival of chemotherapy-resistant CSCs. The present study fastens this rationale for further characterisation that may lead to the discovery of innovative drugs against robust CSCs.",
author = "Jun Koseki and Hidetoshi Matsui and Masamitsu Konno and Naohiro Nishida and Koichi Kawamoto and Yoshihiro Kano and Masaki Mori and Yuichiro Doki and Hideshi Ishii",
note = "Funding Information: We thank the members of our laboratories for fruitful discussions. This work received the following financial support: grants-in-aid for Scientific Research and P-Direct Grants from the Ministry of Education, Culture, Sports, Science, and Technology (HM, MK, MM, YD and HI); a grantin-aid from the Ministry of Health, Labour, and Welfare (MK, HI and MM); a grant from the Kobayashi Cancer Research Foundation (HI); a grant from the Princess Takamatsu Cancer Research Fund, Japan (HI); a grant from the National Institute of Biomedical Innovation (MK, HI and MM) and a grant from the Osaka University Drug Discovery Funds (NN, JK, KK, MK, MM and HI). Partial support was received from Takeda Science and Medical Research Foundation through institutional endowments (MM and HI), Princess Takamatsu Cancer Research Fund (MM and HI), Kobayashi Cancer Research Foundation (MM and HI), Suzuken Memorial Foundation (MK), Yasuda Medical Foundation (NN), Pancreas Research Foundation of Japan (KK) and the Nakatomi Foundation (MK). Institutional endowments were received partially from Taiho Pharmaceutical Co., Ltd.; Evidence Based Medical (EBM) Research Center, Yakult Honsha Co., Ltd.; Chugai Co., Ltd.; and Merck Co., Ltd.",
year = "2016",
month = feb,
day = "11",
doi = "10.1038/srep20726",
language = "English",
volume = "6",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
}
