A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells

Jun Koseki, Hidetoshi Matsui, Masamitsu Konno, Naohiro Nishida, Koichi Kawamoto, Yoshihiro Kano, Masaki Mori, Yuichiro Doki, Hideshi Ishii

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Bioinformatics and computational modelling are expected to offer innovative approaches in human medical science. In the present study, we performed computational analyses and made predictions using transcriptome and metabolome datasets obtained from fluorescence-based visualisations of chemotherapy-resistant cancer stem cells (CSCs) in the human oesophagus. This approach revealed an uncharacterized role for the ornithine metabolic pathway in the survival of chemotherapy-resistant CSCs. The present study fastens this rationale for further characterisation that may lead to the discovery of innovative drugs against robust CSCs.

Original languageEnglish
Article number20726
JournalScientific reports
Volume6
DOIs
Publication statusPublished - Feb 11 2016
Externally publishedYes

All Science Journal Classification (ASJC) codes

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    Koseki, J., Matsui, H., Konno, M., Nishida, N., Kawamoto, K., Kano, Y., Mori, M., Doki, Y., & Ishii, H. (2016). A Trans-omics Mathematical Analysis Reveals Novel Functions of the Ornithine Metabolic Pathway in Cancer Stem Cells. Scientific reports, 6, [20726]. https://doi.org/10.1038/srep20726