TY - JOUR
T1 - A trip of peptides to the brain
AU - Matsui, Toshiro
AU - Yoshino, Atsuko
AU - Tanaka, Mitsuru
N1 - Funding Information:
The authors thank Dr. Dohgu S. and Dr. Takata F. for their contributory efforts to brain perfusion study.
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12
Y1 - 2020/12
N2 - Abstract: Dietary di/tripeptides elicit preventive effects against lifestyle-related diseases such as hypertension, and hypercholesterolemia, etc. Although there have been evidential reports that the intake of protein hydrolysate improved impaired memory in human, limited studies on bioavailability, in particular, beyond the blood-brain barrier (BBB) of candidates in hydrolysate may prevent their extensive physiological studies. Thus, this review discusses the updated studies on BBB transport of peptides showing improved cognitive decline. Furthermore, their accumulation in the brain cerebral parenchyma is also introduced. Graphical abstract: [Figure not available: see fulltext.]
AB - Abstract: Dietary di/tripeptides elicit preventive effects against lifestyle-related diseases such as hypertension, and hypercholesterolemia, etc. Although there have been evidential reports that the intake of protein hydrolysate improved impaired memory in human, limited studies on bioavailability, in particular, beyond the blood-brain barrier (BBB) of candidates in hydrolysate may prevent their extensive physiological studies. Thus, this review discusses the updated studies on BBB transport of peptides showing improved cognitive decline. Furthermore, their accumulation in the brain cerebral parenchyma is also introduced. Graphical abstract: [Figure not available: see fulltext.]
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U2 - 10.1186/s43014-020-00044-8
DO - 10.1186/s43014-020-00044-8
M3 - Review article
AN - SCOPUS:85124724407
VL - 2
JO - Food Production, Processing and Nutrition
JF - Food Production, Processing and Nutrition
SN - 2661-8974
IS - 1
M1 - 30
ER -
