A tris(2,2′-bipyridine)ruthenium(ii) derivative tethered to a cis-PtCl2(amine)2 moiety: Syntheses, spectroscopic properties, and visible-light-induced scission of DNA

Ken Sakai, Hironobu Ozawa, Hajime Yamada, Taro Tsubomura, Mariko Hara, Akon Higuchi, Masa Aki Haga

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

A tris(2,2′-bipyridine)ruthenium(ii) derivative having two N-(3-ammoniopropyl)carbamoyl pendant units has been prepared and reacted with cis-PtCl2(DMSO)2 (DMSO = dimethyl sulfoxide) to give a heteronuclear Ru(ii)Pt(ii) dimer having a cis-Pt(ii)Cl2(aliphatic amine)2 unit, [Ru(bpy)2(-bridge)PtCl2](PF 6)2 (bpy = 2,2′-bipyridine, bridge = 4,4′-bis(N-(3-aminopropyl)carbamoyl)-2,2′-bipyridine). The ESI-TOF mass spectrum of the Ru(ii)Pt(ii) dimer shows a set of signals corresponding to {[Ru(bpy)2(-bridge)PtCl2](PF6)}+ (m/z 1181.1). The MLCT (metal-to-ligand charge transfer) luminescence intensity is enhanced upon the platination of two amine units, presumably due to the formation of a relatively rigid metallocycle. More interestingly, the luminescence intensity is further enhanced by the complexation of the Ru(ii)Pt(ii) dimer with either 5′-GMP (guanosine 5′-monophosphate disodium salt) or calf thymus DNA. Visible-light-induced scission of supercoiled pBR322 DNA is found to be efficiently enhanced in the presence of the title Ru(ii)Pt(ii) dimer.

Original languageEnglish
Pages (from-to)3300-3305
Number of pages6
JournalDalton Transactions
Issue number27
DOIs
Publication statusPublished - 2006

All Science Journal Classification (ASJC) codes

  • Inorganic Chemistry

Fingerprint Dive into the research topics of 'A tris(2,2′-bipyridine)ruthenium(ii) derivative tethered to a cis-PtCl<sub>2</sub>(amine)<sub>2</sub> moiety: Syntheses, spectroscopic properties, and visible-light-induced scission of DNA'. Together they form a unique fingerprint.

Cite this