A turn-on near-infrared fluorescence probe with aggregation-induced emission based on dibenzo[: A, c] phenazine for detection of superoxide anions and its application in cell imaging

Ji Yang, Xianglong Liu, Honglei Wang, Haoqi Tan, Xiaoxu Xie, Xiao Zhang, Chenchen Liu, Xue Qu, Jianli Hua

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

A new turn-on near-infrared fluorescence probe (BDP) based on dibenzo[a,c]phenazine for superoxide anion detection with aggregation-induced emission properties as well as a desirable large Stokes shift was designed and synthesized. After BDP reacted with superoxide, the initial diphenyl-phosphinyl groups of BDP were cleaved, resulting in the production of the pyridinium modified fluorophore (BD) with near-infrared emission. The fluorescent sensor BDP has a high selectivity for superoxide anions over some other intracellular ROSs, reductants, metal ions and amino acids. When HepG2 cells undergo apoptosis and inflammation, BDP is a good probe to keep track of the endogenous superoxide anion level by confocal laser scanning microscopic imaging.

Original languageEnglish
Pages (from-to)1242-1249
Number of pages8
JournalAnalyst
Volume143
Issue number5
DOIs
Publication statusPublished - Mar 7 2018
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Environmental Chemistry
  • Spectroscopy
  • Electrochemistry

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