TY - JOUR
T1 - A turn-on near-infrared fluorescence probe with aggregation-induced emission based on dibenzo[
T2 - A, c] phenazine for detection of superoxide anions and its application in cell imaging
AU - Yang, Ji
AU - Liu, Xianglong
AU - Wang, Honglei
AU - Tan, Haoqi
AU - Xie, Xiaoxu
AU - Zhang, Xiao
AU - Liu, Chenchen
AU - Qu, Xue
AU - Hua, Jianli
N1 - Funding Information:
This work was supported by the NSFC/China (21421004, 21372082, 21572062, 21772040 and 51573047), the Fundamental Research Funds for the Central Universities (222201717003) and the Programme of Introducing Talents of Discipline to Universities (B16017).
Publisher Copyright:
© 2018 The Royal Society of Chemistry.
PY - 2018/3/7
Y1 - 2018/3/7
N2 - A new turn-on near-infrared fluorescence probe (BDP) based on dibenzo[a,c]phenazine for superoxide anion detection with aggregation-induced emission properties as well as a desirable large Stokes shift was designed and synthesized. After BDP reacted with superoxide, the initial diphenyl-phosphinyl groups of BDP were cleaved, resulting in the production of the pyridinium modified fluorophore (BD) with near-infrared emission. The fluorescent sensor BDP has a high selectivity for superoxide anions over some other intracellular ROSs, reductants, metal ions and amino acids. When HepG2 cells undergo apoptosis and inflammation, BDP is a good probe to keep track of the endogenous superoxide anion level by confocal laser scanning microscopic imaging.
AB - A new turn-on near-infrared fluorescence probe (BDP) based on dibenzo[a,c]phenazine for superoxide anion detection with aggregation-induced emission properties as well as a desirable large Stokes shift was designed and synthesized. After BDP reacted with superoxide, the initial diphenyl-phosphinyl groups of BDP were cleaved, resulting in the production of the pyridinium modified fluorophore (BD) with near-infrared emission. The fluorescent sensor BDP has a high selectivity for superoxide anions over some other intracellular ROSs, reductants, metal ions and amino acids. When HepG2 cells undergo apoptosis and inflammation, BDP is a good probe to keep track of the endogenous superoxide anion level by confocal laser scanning microscopic imaging.
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U2 - 10.1039/c7an01860f
DO - 10.1039/c7an01860f
M3 - Article
C2 - 29431796
AN - SCOPUS:85042733718
VL - 143
SP - 1242
EP - 1249
JO - The Analyst
JF - The Analyst
SN - 0003-2654
IS - 5
ER -